Expression of maspin in invasive fungal rhinosinusitis
This study aimed to test the expression of maspin in invasive fungal rhinosinusitis and explore its value in diagnosing invasive fungal rhinosinusitis. Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases...
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| Veröffentlicht in: | Journal of laryngology and otology 2017-02, Vol.131 (2), p.150-154 |
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| creator | Huang, Y D Yu, H W Xia, S W Kang, Z H He, Y S Han, D Y |
| description | This study aimed to test the expression of maspin in invasive fungal rhinosinusitis and explore its value in diagnosing invasive fungal rhinosinusitis.
Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases comprised the control group. Maspin expression was assessed in nasal mucous membrane specimens by immunohistochemical staining.
Compared with the control group, maspin expression was down-regulated in the fungal rhinosinusitis group (p < 0.05). Furthermore, the staining score for maspin was lowest in the invasive fungal rhinosinusitis group, as compared with both the non-invasive fungal rhinosinusitis group and the control group (p < 0.05). A maspin staining score of 5.70 was the critical value for diagnosis of invasive fungal rhinosinusitis, with sensitivity and specificity of 91.7 per cent and 88.3 per cent, respectively.
The results of this study suggest that the maspin staining score may be a biomarker for effective and rapid diagnosis of invasive fungal rhinosinusitis. |
| doi_str_mv | 10.1017/S0022215116009890 |
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Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases comprised the control group. Maspin expression was assessed in nasal mucous membrane specimens by immunohistochemical staining.
Compared with the control group, maspin expression was down-regulated in the fungal rhinosinusitis group (p < 0.05). Furthermore, the staining score for maspin was lowest in the invasive fungal rhinosinusitis group, as compared with both the non-invasive fungal rhinosinusitis group and the control group (p < 0.05). A maspin staining score of 5.70 was the critical value for diagnosis of invasive fungal rhinosinusitis, with sensitivity and specificity of 91.7 per cent and 88.3 per cent, respectively.
The results of this study suggest that the maspin staining score may be a biomarker for effective and rapid diagnosis of invasive fungal rhinosinusitis.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215116009890</identifier><identifier>PMID: 28031066</identifier><identifier>CODEN: JLOTAX</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Biotechnology ; Case-Control Studies ; Female ; Fungi ; Granulomas ; Humans ; Immunohistochemistry ; Infectious diseases ; Invasive Fungal Infections - diagnosis ; Invasive Fungal Infections - metabolism ; Main Articles ; Male ; Middle Aged ; Mycoses - metabolism ; Nasal Mucosa - metabolism ; Polyclonal antibodies ; Proteins ; Rhinitis - diagnosis ; Rhinitis - metabolism ; Sensitivity and Specificity ; Serpins - metabolism ; Sinusitis - diagnosis ; Sinusitis - metabolism ; Statistical analysis ; Young Adult</subject><ispartof>Journal of laryngology and otology, 2017-02, Vol.131 (2), p.150-154</ispartof><rights>Copyright © JLO (1984) Limited 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-a860c9e0563d035f77296897bb95a5e5866c9e2fa8564864b1b6eeb5429358f3</citedby><cites>FETCH-LOGICAL-c406t-a860c9e0563d035f77296897bb95a5e5866c9e2fa8564864b1b6eeb5429358f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215116009890/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28031066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Y D</creatorcontrib><creatorcontrib>Yu, H W</creatorcontrib><creatorcontrib>Xia, S W</creatorcontrib><creatorcontrib>Kang, Z H</creatorcontrib><creatorcontrib>He, Y S</creatorcontrib><creatorcontrib>Han, D Y</creatorcontrib><title>Expression of maspin in invasive fungal rhinosinusitis</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>This study aimed to test the expression of maspin in invasive fungal rhinosinusitis and explore its value in diagnosing invasive fungal rhinosinusitis.
Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases comprised the control group. Maspin expression was assessed in nasal mucous membrane specimens by immunohistochemical staining.
Compared with the control group, maspin expression was down-regulated in the fungal rhinosinusitis group (p < 0.05). Furthermore, the staining score for maspin was lowest in the invasive fungal rhinosinusitis group, as compared with both the non-invasive fungal rhinosinusitis group and the control group (p < 0.05). A maspin staining score of 5.70 was the critical value for diagnosis of invasive fungal rhinosinusitis, with sensitivity and specificity of 91.7 per cent and 88.3 per cent, respectively.
The results of this study suggest that the maspin staining score may be a biomarker for effective and rapid diagnosis of invasive fungal rhinosinusitis.</description><subject>Adult</subject><subject>Aged</subject><subject>Biotechnology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Fungi</subject><subject>Granulomas</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infectious diseases</subject><subject>Invasive Fungal Infections - diagnosis</subject><subject>Invasive Fungal Infections - metabolism</subject><subject>Main Articles</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycoses - metabolism</subject><subject>Nasal Mucosa - metabolism</subject><subject>Polyclonal antibodies</subject><subject>Proteins</subject><subject>Rhinitis - diagnosis</subject><subject>Rhinitis - metabolism</subject><subject>Sensitivity and Specificity</subject><subject>Serpins - metabolism</subject><subject>Sinusitis - diagnosis</subject><subject>Sinusitis - metabolism</subject><subject>Statistical analysis</subject><subject>Young Adult</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkM1LAzEQxYMotlb_AC-y4MXL6iS7mU2OUuoHCB7sfcluszVlP2qmW_S_N7VVRBGEgRze772ZPMZOOVxy4NnVE4AQgkvOEUArDXtsyLNUxTJF2GfDjRxv9AE7IloABBOIQzYQChIOiEOGk9elt0Sua6OuihpDS9dGH7M25NY2qvp2burIP7u2I9f25FaOjtlBZWqyJ7t3xKY3k-n4Ln54vL0fXz_EZQq4io1CKLUFickMElllmdCodFYUWhpppUIMsqiMkpgqTAteoLWFTIVOpKqSEbvYxi5999JbWuWNo9LWtWlt11POVSaUUCH2H6hMOYRidEDPf6CLrvdt-EegUGZJuIQHim-p0ndE3lb50rvG-LecQ76pP_9Vf_Cc7ZL7orGzL8dn3wFIdqGmKbybze233X_GvgNN4owM</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Huang, Y D</creator><creator>Yu, H W</creator><creator>Xia, S W</creator><creator>Kang, Z H</creator><creator>He, Y S</creator><creator>Han, D Y</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>M7N</scope></search><sort><creationdate>201702</creationdate><title>Expression of maspin in invasive fungal rhinosinusitis</title><author>Huang, Y D ; Yu, H W ; Xia, S W ; Kang, Z H ; He, Y S ; Han, D Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-a860c9e0563d035f77296897bb95a5e5866c9e2fa8564864b1b6eeb5429358f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biotechnology</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Fungi</topic><topic>Granulomas</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infectious diseases</topic><topic>Invasive Fungal Infections - diagnosis</topic><topic>Invasive Fungal Infections - metabolism</topic><topic>Main Articles</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mycoses - metabolism</topic><topic>Nasal Mucosa - metabolism</topic><topic>Polyclonal antibodies</topic><topic>Proteins</topic><topic>Rhinitis - diagnosis</topic><topic>Rhinitis - metabolism</topic><topic>Sensitivity and Specificity</topic><topic>Serpins - metabolism</topic><topic>Sinusitis - diagnosis</topic><topic>Sinusitis - metabolism</topic><topic>Statistical analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Y D</creatorcontrib><creatorcontrib>Yu, H W</creatorcontrib><creatorcontrib>Xia, S W</creatorcontrib><creatorcontrib>Kang, Z H</creatorcontrib><creatorcontrib>He, Y S</creatorcontrib><creatorcontrib>Han, D Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Y D</au><au>Yu, H W</au><au>Xia, S W</au><au>Kang, Z H</au><au>He, Y S</au><au>Han, D Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of maspin in invasive fungal rhinosinusitis</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>2017-02</date><risdate>2017</risdate><volume>131</volume><issue>2</issue><spage>150</spage><epage>154</epage><pages>150-154</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><coden>JLOTAX</coden><abstract>This study aimed to test the expression of maspin in invasive fungal rhinosinusitis and explore its value in diagnosing invasive fungal rhinosinusitis.
Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases comprised the control group. Maspin expression was assessed in nasal mucous membrane specimens by immunohistochemical staining.
Compared with the control group, maspin expression was down-regulated in the fungal rhinosinusitis group (p < 0.05). Furthermore, the staining score for maspin was lowest in the invasive fungal rhinosinusitis group, as compared with both the non-invasive fungal rhinosinusitis group and the control group (p < 0.05). A maspin staining score of 5.70 was the critical value for diagnosis of invasive fungal rhinosinusitis, with sensitivity and specificity of 91.7 per cent and 88.3 per cent, respectively.
The results of this study suggest that the maspin staining score may be a biomarker for effective and rapid diagnosis of invasive fungal rhinosinusitis.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>28031066</pmid><doi>10.1017/S0022215116009890</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Biotechnology Case-Control Studies Female Fungi Granulomas Humans Immunohistochemistry Infectious diseases Invasive Fungal Infections - diagnosis Invasive Fungal Infections - metabolism Main Articles Male Middle Aged Mycoses - metabolism Nasal Mucosa - metabolism Polyclonal antibodies Proteins Rhinitis - diagnosis Rhinitis - metabolism Sensitivity and Specificity Serpins - metabolism Sinusitis - diagnosis Sinusitis - metabolism Statistical analysis Young Adult |
| title | Expression of maspin in invasive fungal rhinosinusitis |
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