Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision‐cut rat liver slices

ABSTRACT The current studies investigate whether synergistic or antagonistic interactions in the upregulation of CYP1 activity occur in binary mixtures of polycyclic aromatic hydrocarbons (PAHs) involving benzo[a]pyrene and five other structurally diverse PAHs of varying carcinogenic activity. Preci...

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Veröffentlicht in:	Environmental toxicology 2017-03, Vol.32 (3), p.764-775
Hauptverfasser:	Pushparajah, Daphnee S., Plant, Kathryn E., Plant, Nick J., Ioannides, Costas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benz(a)Anthracenes - toxicity Benzo(a)pyrene - toxicity Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1B1 - metabolism cytochrome P450 Drug Synergism In Vitro Techniques interactions Liver - drug effects Liver - metabolism Male polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - toxicity precision‐cut tissue slices Rats Rats, Wistar risk assessment RNA, Messenger - metabolism Up-Regulation - drug effects
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