Twenty‐eight years of intestinal transplantation in Paris: experience of the oldest European center
Summary Our aim was to describe our achievements in pediatric intestinal transplantation (ITx) and define areas for improvement. After a period (1987–1990) of nine isolated small bowel transplants (SBTx) where only one patient survived with her graft, 110 ITx were performed on 101 children from 1994...
Gespeichert in:
| Veröffentlicht in: | Transplant international 2017-02, Vol.30 (2), p.178-186 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 186 |
|---|---|
| container_issue | 2 |
| container_start_page | 178 |
| container_title | Transplant international |
| container_volume | 30 |
| creator | Lacaille, Florence Irtan, Sabine Dupic, Laurent Talbotec, Cécile Lesage, Fabrice Colomb, Virinie Salvi, Nadège Moulin, Florence Sauvat, Frédérique Aigrain, Yves Revillon, Yann Goulet, Olivier Chardot, Christophe |
| description | Summary
Our aim was to describe our achievements in pediatric intestinal transplantation (ITx) and define areas for improvement. After a period (1987–1990) of nine isolated small bowel transplants (SBTx) where only one patient survived with her graft, 110 ITx were performed on 101 children from 1994 to 2014: 60 SBTx, 45 liver–small bowel, four multivisceral (three with kidneys), and one modified multivisceral. Indications were short bowel syndrome (36), motility disorders (30), congenital enteropathies (34), and others (1). Induction treatment was introduced in 2000. Patient/graft survival with a liver‐containing graft or SBTx was, respectively, 60/41% and 46/11% at 18 years. Recently, graft survival at 5/10 years was 44% and 31% for liver‐containing graft and 57% and 44% for SBTx. Late graft loss occurred in 13 patients, and 7 of 10 retransplanted patients died. The main causes of death and graft loss were sepsis and rejection. Among the 55 currently living patients, 21 had a liver‐containing graft, 19 a SBTx (17 after induction), and 15 were on parenteral nutrition. ITx remains a difficult procedure, and retransplantation even more so. Over the long term, graft loss was due to rejection, over‐immunosuppression was not a significant problem. Multicenter studies on immunosuppression and microbiota are urgently needed. |
| doi_str_mv | 10.1111/tri.12894 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1872827924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4312656241</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4214-e9cfdde96355be71cad69a628d72b07a249492bc08f1e6c971e4e939b942013b3</originalsourceid><addsrcrecordid>eNqNkc9O3DAQh60KVJZtD30BFIlLOQTsieM_3BCiFAmJqtqeI8eZgFE2SW1HsLc-Qp-RJ8HLbjlUQmIuc5hvPo3mR8gXRo9ZqpPo3TEDpfkHMmO8gBxAyh0yo7rgOVWS75H9EO4ppaBK-pHsgVRKa9AzgosH7OPq6c9fdLd3MVuh8SEb2sz1EUN0vemy6E0fxs700UQ39GmU_TDehdMMH0f0DnuL65V4l1rXpLXsYvLDiKbPbLKj_0R2W9MF_Lztc_Lr28Xi_Ht-fXN5dX52nVsOjOeobds0qEVRljVKZk0jtBGgGgk1lQa45hpqS1XLUFgtGXLUha41B8qKupiTrxvv6IffUzqkWrpgsUu34zCFiikJCqQG_g6U86IEwURCD_9D74fJp8-sKVEKoZgsE3W0oawfQvDYVqN3S-NXFaPVOqYqxVS9xJTYg61xqpfYvJL_cknAyQZ4cB2u3jZVi59XG-UzcZOdOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865668175</pqid></control><display><type>article</type><title>Twenty‐eight years of intestinal transplantation in Paris: experience of the oldest European center</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Lacaille, Florence ; Irtan, Sabine ; Dupic, Laurent ; Talbotec, Cécile ; Lesage, Fabrice ; Colomb, Virinie ; Salvi, Nadège ; Moulin, Florence ; Sauvat, Frédérique ; Aigrain, Yves ; Revillon, Yann ; Goulet, Olivier ; Chardot, Christophe</creator><creatorcontrib>Lacaille, Florence ; Irtan, Sabine ; Dupic, Laurent ; Talbotec, Cécile ; Lesage, Fabrice ; Colomb, Virinie ; Salvi, Nadège ; Moulin, Florence ; Sauvat, Frédérique ; Aigrain, Yves ; Revillon, Yann ; Goulet, Olivier ; Chardot, Christophe</creatorcontrib><description>Summary
Our aim was to describe our achievements in pediatric intestinal transplantation (ITx) and define areas for improvement. After a period (1987–1990) of nine isolated small bowel transplants (SBTx) where only one patient survived with her graft, 110 ITx were performed on 101 children from 1994 to 2014: 60 SBTx, 45 liver–small bowel, four multivisceral (three with kidneys), and one modified multivisceral. Indications were short bowel syndrome (36), motility disorders (30), congenital enteropathies (34), and others (1). Induction treatment was introduced in 2000. Patient/graft survival with a liver‐containing graft or SBTx was, respectively, 60/41% and 46/11% at 18 years. Recently, graft survival at 5/10 years was 44% and 31% for liver‐containing graft and 57% and 44% for SBTx. Late graft loss occurred in 13 patients, and 7 of 10 retransplanted patients died. The main causes of death and graft loss were sepsis and rejection. Among the 55 currently living patients, 21 had a liver‐containing graft, 19 a SBTx (17 after induction), and 15 were on parenteral nutrition. ITx remains a difficult procedure, and retransplantation even more so. Over the long term, graft loss was due to rejection, over‐immunosuppression was not a significant problem. Multicenter studies on immunosuppression and microbiota are urgently needed.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/tri.12894</identifier><identifier>PMID: 27889929</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Child ; Child, Preschool ; Comorbidity ; graft loss ; Graft Survival ; History, 20th Century ; History, 21st Century ; Humans ; Infant ; intestinal transplantation ; Intestines - transplantation ; multivisceral transplantation ; Paris - epidemiology ; Pediatrics - history ; Reoperation ; survival ; Transplantation - adverse effects ; Transplantation - history ; Transplantation - mortality ; Transplantation Immunology ; Young Adult</subject><ispartof>Transplant international, 2017-02, Vol.30 (2), p.178-186</ispartof><rights>2016 Steunstichting ESOT</rights><rights>2016 Steunstichting ESOT.</rights><rights>Copyright © 2017 Steunstichting ESOT. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4214-e9cfdde96355be71cad69a628d72b07a249492bc08f1e6c971e4e939b942013b3</citedby><cites>FETCH-LOGICAL-c4214-e9cfdde96355be71cad69a628d72b07a249492bc08f1e6c971e4e939b942013b3</cites><orcidid>0000-0001-5596-9570</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftri.12894$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftri.12894$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27889929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lacaille, Florence</creatorcontrib><creatorcontrib>Irtan, Sabine</creatorcontrib><creatorcontrib>Dupic, Laurent</creatorcontrib><creatorcontrib>Talbotec, Cécile</creatorcontrib><creatorcontrib>Lesage, Fabrice</creatorcontrib><creatorcontrib>Colomb, Virinie</creatorcontrib><creatorcontrib>Salvi, Nadège</creatorcontrib><creatorcontrib>Moulin, Florence</creatorcontrib><creatorcontrib>Sauvat, Frédérique</creatorcontrib><creatorcontrib>Aigrain, Yves</creatorcontrib><creatorcontrib>Revillon, Yann</creatorcontrib><creatorcontrib>Goulet, Olivier</creatorcontrib><creatorcontrib>Chardot, Christophe</creatorcontrib><title>Twenty‐eight years of intestinal transplantation in Paris: experience of the oldest European center</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
Our aim was to describe our achievements in pediatric intestinal transplantation (ITx) and define areas for improvement. After a period (1987–1990) of nine isolated small bowel transplants (SBTx) where only one patient survived with her graft, 110 ITx were performed on 101 children from 1994 to 2014: 60 SBTx, 45 liver–small bowel, four multivisceral (three with kidneys), and one modified multivisceral. Indications were short bowel syndrome (36), motility disorders (30), congenital enteropathies (34), and others (1). Induction treatment was introduced in 2000. Patient/graft survival with a liver‐containing graft or SBTx was, respectively, 60/41% and 46/11% at 18 years. Recently, graft survival at 5/10 years was 44% and 31% for liver‐containing graft and 57% and 44% for SBTx. Late graft loss occurred in 13 patients, and 7 of 10 retransplanted patients died. The main causes of death and graft loss were sepsis and rejection. Among the 55 currently living patients, 21 had a liver‐containing graft, 19 a SBTx (17 after induction), and 15 were on parenteral nutrition. ITx remains a difficult procedure, and retransplantation even more so. Over the long term, graft loss was due to rejection, over‐immunosuppression was not a significant problem. Multicenter studies on immunosuppression and microbiota are urgently needed.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Comorbidity</subject><subject>graft loss</subject><subject>Graft Survival</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Infant</subject><subject>intestinal transplantation</subject><subject>Intestines - transplantation</subject><subject>multivisceral transplantation</subject><subject>Paris - epidemiology</subject><subject>Pediatrics - history</subject><subject>Reoperation</subject><subject>survival</subject><subject>Transplantation - adverse effects</subject><subject>Transplantation - history</subject><subject>Transplantation - mortality</subject><subject>Transplantation Immunology</subject><subject>Young Adult</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9O3DAQh60KVJZtD30BFIlLOQTsieM_3BCiFAmJqtqeI8eZgFE2SW1HsLc-Qp-RJ8HLbjlUQmIuc5hvPo3mR8gXRo9ZqpPo3TEDpfkHMmO8gBxAyh0yo7rgOVWS75H9EO4ppaBK-pHsgVRKa9AzgosH7OPq6c9fdLd3MVuh8SEb2sz1EUN0vemy6E0fxs700UQ39GmU_TDehdMMH0f0DnuL65V4l1rXpLXsYvLDiKbPbLKj_0R2W9MF_Lztc_Lr28Xi_Ht-fXN5dX52nVsOjOeobds0qEVRljVKZk0jtBGgGgk1lQa45hpqS1XLUFgtGXLUha41B8qKupiTrxvv6IffUzqkWrpgsUu34zCFiikJCqQG_g6U86IEwURCD_9D74fJp8-sKVEKoZgsE3W0oawfQvDYVqN3S-NXFaPVOqYqxVS9xJTYg61xqpfYvJL_cknAyQZ4cB2u3jZVi59XG-UzcZOdOw</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Lacaille, Florence</creator><creator>Irtan, Sabine</creator><creator>Dupic, Laurent</creator><creator>Talbotec, Cécile</creator><creator>Lesage, Fabrice</creator><creator>Colomb, Virinie</creator><creator>Salvi, Nadège</creator><creator>Moulin, Florence</creator><creator>Sauvat, Frédérique</creator><creator>Aigrain, Yves</creator><creator>Revillon, Yann</creator><creator>Goulet, Olivier</creator><creator>Chardot, Christophe</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5596-9570</orcidid></search><sort><creationdate>201702</creationdate><title>Twenty‐eight years of intestinal transplantation in Paris: experience of the oldest European center</title><author>Lacaille, Florence ; Irtan, Sabine ; Dupic, Laurent ; Talbotec, Cécile ; Lesage, Fabrice ; Colomb, Virinie ; Salvi, Nadège ; Moulin, Florence ; Sauvat, Frédérique ; Aigrain, Yves ; Revillon, Yann ; Goulet, Olivier ; Chardot, Christophe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4214-e9cfdde96355be71cad69a628d72b07a249492bc08f1e6c971e4e939b942013b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Comorbidity</topic><topic>graft loss</topic><topic>Graft Survival</topic><topic>History, 20th Century</topic><topic>History, 21st Century</topic><topic>Humans</topic><topic>Infant</topic><topic>intestinal transplantation</topic><topic>Intestines - transplantation</topic><topic>multivisceral transplantation</topic><topic>Paris - epidemiology</topic><topic>Pediatrics - history</topic><topic>Reoperation</topic><topic>survival</topic><topic>Transplantation - adverse effects</topic><topic>Transplantation - history</topic><topic>Transplantation - mortality</topic><topic>Transplantation Immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lacaille, Florence</creatorcontrib><creatorcontrib>Irtan, Sabine</creatorcontrib><creatorcontrib>Dupic, Laurent</creatorcontrib><creatorcontrib>Talbotec, Cécile</creatorcontrib><creatorcontrib>Lesage, Fabrice</creatorcontrib><creatorcontrib>Colomb, Virinie</creatorcontrib><creatorcontrib>Salvi, Nadège</creatorcontrib><creatorcontrib>Moulin, Florence</creatorcontrib><creatorcontrib>Sauvat, Frédérique</creatorcontrib><creatorcontrib>Aigrain, Yves</creatorcontrib><creatorcontrib>Revillon, Yann</creatorcontrib><creatorcontrib>Goulet, Olivier</creatorcontrib><creatorcontrib>Chardot, Christophe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lacaille, Florence</au><au>Irtan, Sabine</au><au>Dupic, Laurent</au><au>Talbotec, Cécile</au><au>Lesage, Fabrice</au><au>Colomb, Virinie</au><au>Salvi, Nadège</au><au>Moulin, Florence</au><au>Sauvat, Frédérique</au><au>Aigrain, Yves</au><au>Revillon, Yann</au><au>Goulet, Olivier</au><au>Chardot, Christophe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Twenty‐eight years of intestinal transplantation in Paris: experience of the oldest European center</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2017-02</date><risdate>2017</risdate><volume>30</volume><issue>2</issue><spage>178</spage><epage>186</epage><pages>178-186</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
Our aim was to describe our achievements in pediatric intestinal transplantation (ITx) and define areas for improvement. After a period (1987–1990) of nine isolated small bowel transplants (SBTx) where only one patient survived with her graft, 110 ITx were performed on 101 children from 1994 to 2014: 60 SBTx, 45 liver–small bowel, four multivisceral (three with kidneys), and one modified multivisceral. Indications were short bowel syndrome (36), motility disorders (30), congenital enteropathies (34), and others (1). Induction treatment was introduced in 2000. Patient/graft survival with a liver‐containing graft or SBTx was, respectively, 60/41% and 46/11% at 18 years. Recently, graft survival at 5/10 years was 44% and 31% for liver‐containing graft and 57% and 44% for SBTx. Late graft loss occurred in 13 patients, and 7 of 10 retransplanted patients died. The main causes of death and graft loss were sepsis and rejection. Among the 55 currently living patients, 21 had a liver‐containing graft, 19 a SBTx (17 after induction), and 15 were on parenteral nutrition. ITx remains a difficult procedure, and retransplantation even more so. Over the long term, graft loss was due to rejection, over‐immunosuppression was not a significant problem. Multicenter studies on immunosuppression and microbiota are urgently needed.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27889929</pmid><doi>10.1111/tri.12894</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5596-9570</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-0874 |
| ispartof | Transplant international, 2017-02, Vol.30 (2), p.178-186 |
| issn | 0934-0874 1432-2277 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1872827924 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Child Child, Preschool Comorbidity graft loss Graft Survival History, 20th Century History, 21st Century Humans Infant intestinal transplantation Intestines - transplantation multivisceral transplantation Paris - epidemiology Pediatrics - history Reoperation survival Transplantation - adverse effects Transplantation - history Transplantation - mortality Transplantation Immunology Young Adult |
| title | Twenty‐eight years of intestinal transplantation in Paris: experience of the oldest European center |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T01%3A46%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Twenty%E2%80%90eight%20years%20of%20intestinal%20transplantation%20in%20Paris:%20experience%20of%20the%20oldest%20European%20center&rft.jtitle=Transplant%20international&rft.au=Lacaille,%20Florence&rft.date=2017-02&rft.volume=30&rft.issue=2&rft.spage=178&rft.epage=186&rft.pages=178-186&rft.issn=0934-0874&rft.eissn=1432-2277&rft_id=info:doi/10.1111/tri.12894&rft_dat=%3Cproquest_cross%3E4312656241%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1865668175&rft_id=info:pmid/27889929&rfr_iscdi=true |