Network‐based characterization of the synaptic proteome reveals that removal of epigenetic regulator Prmt8 restricts proteins associated with synaptic maturation

The brain adapts to dynamic environmental conditions by altering its epigenetic state, thereby influencing neuronal transcriptional programs. An example of an epigenetic modification is protein methylation, catalyzed by protein arginine methyltransferases (PRMT). One member, Prmt8, is selectively ex...

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Veröffentlicht in:	Journal of neurochemistry 2017-02, Vol.140 (4), p.613-628
Hauptverfasser:	Lee, Patrick Kia Ming, Goh, Wilson Wen Bin, Sng, Judy Chia Ghee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Animals Arginine Brain Central nervous system Chromatin Circuits Cortex (somatosensory) Developmental plasticity Discrimination Learning - physiology Environmental conditions Epigenesis, Genetic - physiology Epigenetics Female Functional plasticity Gene Regulatory Networks - physiology Genotypes Immunoprecipitation Inspection Male Maturation Methylation Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Nerve Net - physiology Nervous system Nets Neural networks Neurochemistry neuroepigenetics Neurons Parvalbumin Perineuronal nets protein arginine methyltransferase Protein-Arginine N-Methyltransferases - deficiency Protein-Arginine N-Methyltransferases - genetics Proteins Proteome - biosynthesis Proteome - genetics Proteomes proteomics Pyramidal cells Rodents Structural integrity Structural members Synapses Synapses - genetics Synapses - metabolism Synaptic plasticity Synaptogenesis Tenascin tenascin‐r Transcription Visual acuity visual cortex Visual Cortex - cytology Visual Cortex - physiology Visual perception Visual plasticity
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