Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes

Subjects with severe hyperhomocysteinemia have hypoferric anemia and excessive iron deposition in the liver. Hepcidin, the central regulator of iron homeostasis, plays a key role in iron metabolism. However, the regulation of homocysteine (Hcy) on hepcidin is largely unclear. We conducted experiment...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-03, Vol.471 (2), p.303-308
Hauptverfasser:	Luo, Xiaoqin, Luo, Zhenyu, Zhang, Zihui, Yang, Haixia, Lai, Baochang, Yao, Qinyu, Xiao, Lei, Wang, Nanping
Format:	Artikel
Sprache:	eng
Schlagworte:	ALK2 ALK3 ALK6 anemia BMP4 BMP6 BMP6/SMAD Bone Morphogenetic Protein 6 - metabolism Dose-Response Relationship, Drug Hcy Hep G2 Cells Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Hepcidin Hepcidins - metabolism HJV homeostasis Homocysteine Homocysteine - administration & dosage human cell lines Humans Hyperhomocysteinemia iron absorption liver p-SMAD1/5/8 phosphorylation receptors reverse transcriptase polymerase chain reaction signal transduction Signal Transduction - drug effects Signal Transduction - physiology Smad Proteins - metabolism SMAD1 small interfering RNA Up-Regulation - drug effects Up-Regulation - physiology Western blotting
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