Cystatin C as a Marker of Progressing Cardiovascular Events during Coronary Heart Disease
The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated seru...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017-02, Vol.162 (4), p.421-424 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Gevorgyan, M. M. Voronina, N. P. Goncharova, N. V. Kozaruk, T. V. Russkikh, G. S. Bogdanova, L. A. Korolenko, T. A. |
| description | The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated serum cystatin C, especially in cases with serious risk of cardiovascular complications. In comparison with other indicators of cardiorenal dysfunction, cystatin C can be viewed as an alternative predictor of cardiovascular complications, although its sensitivity is inferior to that of high-sensitivity C-reactive protein and natriuretic peptide. |
| doi_str_mv | 10.1007/s10517-017-3630-4 |
| format | Article |
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M. ; Voronina, N. P. ; Goncharova, N. V. ; Kozaruk, T. V. ; Russkikh, G. S. ; Bogdanova, L. A. ; Korolenko, T. A.</creator><creatorcontrib>Gevorgyan, M. M. ; Voronina, N. P. ; Goncharova, N. V. ; Kozaruk, T. V. ; Russkikh, G. S. ; Bogdanova, L. A. ; Korolenko, T. A.</creatorcontrib><description>The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated serum cystatin C, especially in cases with serious risk of cardiovascular complications. In comparison with other indicators of cardiorenal dysfunction, cystatin C can be viewed as an alternative predictor of cardiovascular complications, although its sensitivity is inferior to that of high-sensitivity C-reactive protein and natriuretic peptide.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-017-3630-4</identifier><identifier>PMID: 28239794</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Cardiovascular diseases ; Case-Control Studies ; Cell Biology ; Comparative analysis ; Coronary artery disease ; Coronary Disease - blood ; Coronary Disease - complications ; Coronary Disease - diagnosis ; Coronary heart disease ; Creatinine - blood ; Cystatin C ; Cystatin C - blood ; Cysteine ; Female ; General Pathology and Pathophysiology ; Health risk assessment ; Heart diseases ; Heart Failure - blood ; Heart Failure - diagnosis ; Heart Failure - etiology ; Humans ; Internal Medicine ; Laboratory Medicine ; Male ; Medical research ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - diagnosis ; Myocardial Infarction - etiology ; Natriuretic Peptide, Brain - blood ; Natriuretic peptides ; Pathology ; Peptide Fragments - blood ; Prognosis ; Proteases ; Urea - blood</subject><ispartof>Bulletin of experimental biology and medicine, 2017-02, Vol.162 (4), p.421-424</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-9e20e9264ff127691dbaa040765b81affd5a73b0852c013d921eb62372548d313</citedby><cites>FETCH-LOGICAL-c470t-9e20e9264ff127691dbaa040765b81affd5a73b0852c013d921eb62372548d313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-017-3630-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-017-3630-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28239794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gevorgyan, M. M.</creatorcontrib><creatorcontrib>Voronina, N. P.</creatorcontrib><creatorcontrib>Goncharova, N. V.</creatorcontrib><creatorcontrib>Kozaruk, T. V.</creatorcontrib><creatorcontrib>Russkikh, G. S.</creatorcontrib><creatorcontrib>Bogdanova, L. A.</creatorcontrib><creatorcontrib>Korolenko, T. A.</creatorcontrib><title>Cystatin C as a Marker of Progressing Cardiovascular Events during Coronary Heart Disease</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated serum cystatin C, especially in cases with serious risk of cardiovascular complications. In comparison with other indicators of cardiorenal dysfunction, cystatin C can be viewed as an alternative predictor of cardiovascular complications, although its sensitivity is inferior to that of high-sensitivity C-reactive protein and natriuretic peptide.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Cell Biology</subject><subject>Comparative analysis</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - diagnosis</subject><subject>Coronary heart disease</subject><subject>Creatinine - blood</subject><subject>Cystatin C</subject><subject>Cystatin C - blood</subject><subject>Cysteine</subject><subject>Female</subject><subject>General Pathology and Pathophysiology</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - etiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - etiology</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Natriuretic peptides</subject><subject>Pathology</subject><subject>Peptide Fragments - blood</subject><subject>Prognosis</subject><subject>Proteases</subject><subject>Urea - blood</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU9v1DAQxS0EotvCB-CCLCGhXtL6TxI7xyptKVJROcCBkzVJJluXbLx4kkr99jjdAi0CWZY19u89eeYx9kaKIymEOSYpCmkykbYutcjyZ2wlC6Mzq5R8zlYiQVlurd1j-0Q3SylK-ZLtKat0Zap8xb7VdzTB5EdecyAO_BPE7xh56PnnGNYRify45jXEzodboHYeIPKzWxwn4t0c7x9DDCPEO36BECd-6gmB8BV70cNA-PrhPGBfz8--1BfZ5dWHj_XJZdbmRkxZhUpgpcq876UyZSW7BkDkwpRFYyX0fVeA0Y2whWqF1F2lJDal0kYVue201AfscOe7jeHHjDS5jacWhwFGDDM5aRNqlalsQt_9hd6EOY7pd05WWlhdFlL9odYwoPNjH6YI7WLqTvLKFlan6Sbq6B9UWh1ufBtG7H26fyJ4_0hwjTBM1xSGefJhpKeg3IFtDEQRe7eNfpPm66RwS-5ul7tLubsld5cnzduHzuZmg91vxa-gE6B2AG2XzDA-av2_rj8B6H-zrw</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Gevorgyan, M. 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M.</au><au>Voronina, N. P.</au><au>Goncharova, N. V.</au><au>Kozaruk, T. V.</au><au>Russkikh, G. S.</au><au>Bogdanova, L. A.</au><au>Korolenko, T. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cystatin C as a Marker of Progressing Cardiovascular Events during Coronary Heart Disease</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>162</volume><issue>4</issue><spage>421</spage><epage>424</epage><pages>421-424</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated serum cystatin C, especially in cases with serious risk of cardiovascular complications. In comparison with other indicators of cardiorenal dysfunction, cystatin C can be viewed as an alternative predictor of cardiovascular complications, although its sensitivity is inferior to that of high-sensitivity C-reactive protein and natriuretic peptide.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28239794</pmid><doi>10.1007/s10517-017-3630-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Biomarkers - blood Biomedical and Life Sciences Biomedicine C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular diseases Case-Control Studies Cell Biology Comparative analysis Coronary artery disease Coronary Disease - blood Coronary Disease - complications Coronary Disease - diagnosis Coronary heart disease Creatinine - blood Cystatin C Cystatin C - blood Cysteine Female General Pathology and Pathophysiology Health risk assessment Heart diseases Heart Failure - blood Heart Failure - diagnosis Heart Failure - etiology Humans Internal Medicine Laboratory Medicine Male Medical research Middle Aged Myocardial Infarction - blood Myocardial Infarction - diagnosis Myocardial Infarction - etiology Natriuretic Peptide, Brain - blood Natriuretic peptides Pathology Peptide Fragments - blood Prognosis Proteases Urea - blood |
| title | Cystatin C as a Marker of Progressing Cardiovascular Events during Coronary Heart Disease |
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