Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals
[Display omitted] Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is...
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| Veröffentlicht in: | International journal of pharmaceutics 2017-04, Vol.521 (1-2), p.374-383 |
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| container_end_page | 383 |
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| container_issue | 1-2 |
| container_start_page | 374 |
| container_title | International journal of pharmaceutics |
| container_volume | 521 |
| creator | Paul, Shubhajit Taylor, Lisa J. Murphy, Brendan Krzyzaniak, Joseph F. Dawson, Neil Mullarney, Matthew P. Meenan, Paul Sun, Changquan Calvin |
| description | [Display omitted]
Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is to identify process parameters and particle properties that can profoundly affect sticking performance. This work was aimed at elucidating the key material properties and compaction parameters that influence punch sticking by statistically analyzing punch sticking data of 24 chemically diverse compounds obtained using a set of tooling with removable upper punch tip. Partial least square (PLS) analysis of the data revealed that particle surface area and tablet tensile strength are the most significant factors attributed to punch sticking. Die-wall pressure, ejection force, and take-off force also correlate with sticking, but to a lesser extent. |
| doi_str_mv | 10.1016/j.ijpharm.2017.02.053 |
| format | Article |
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Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is to identify process parameters and particle properties that can profoundly affect sticking performance. This work was aimed at elucidating the key material properties and compaction parameters that influence punch sticking by statistically analyzing punch sticking data of 24 chemically diverse compounds obtained using a set of tooling with removable upper punch tip. Partial least square (PLS) analysis of the data revealed that particle surface area and tablet tensile strength are the most significant factors attributed to punch sticking. Die-wall pressure, ejection force, and take-off force also correlate with sticking, but to a lesser extent.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2017.02.053</identifier><identifier>PMID: 28232264</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Least-Squares Analysis ; Linear regression ; Particle Size ; PLS analysis ; Porosity ; Powder compaction ; Powders ; Sticking ; Surface area ; Surface Properties ; Tablets ; Technology, Pharmaceutical ; Tensile Strength</subject><ispartof>International journal of pharmaceutics, 2017-04, Vol.521 (1-2), p.374-383</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-4f3501530522336a969af0926a8783d6f05f842f7a1d701d3d9c2afa07f7645c3</citedby><cites>FETCH-LOGICAL-c365t-4f3501530522336a969af0926a8783d6f05f842f7a1d701d3d9c2afa07f7645c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517317301436$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27902,27903,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28232264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paul, Shubhajit</creatorcontrib><creatorcontrib>Taylor, Lisa J.</creatorcontrib><creatorcontrib>Murphy, Brendan</creatorcontrib><creatorcontrib>Krzyzaniak, Joseph F.</creatorcontrib><creatorcontrib>Dawson, Neil</creatorcontrib><creatorcontrib>Mullarney, Matthew P.</creatorcontrib><creatorcontrib>Meenan, Paul</creatorcontrib><creatorcontrib>Sun, Changquan Calvin</creatorcontrib><title>Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is to identify process parameters and particle properties that can profoundly affect sticking performance. This work was aimed at elucidating the key material properties and compaction parameters that influence punch sticking by statistically analyzing punch sticking data of 24 chemically diverse compounds obtained using a set of tooling with removable upper punch tip. Partial least square (PLS) analysis of the data revealed that particle surface area and tablet tensile strength are the most significant factors attributed to punch sticking. Die-wall pressure, ejection force, and take-off force also correlate with sticking, but to a lesser extent.</description><subject>Least-Squares Analysis</subject><subject>Linear regression</subject><subject>Particle Size</subject><subject>PLS analysis</subject><subject>Porosity</subject><subject>Powder compaction</subject><subject>Powders</subject><subject>Sticking</subject><subject>Surface area</subject><subject>Surface Properties</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical</subject><subject>Tensile Strength</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1uFDEQhC1ERJbAIwT5yGUmbXtsz54iFJGAFAkO4WwZu531ZucH25Mob4-X3XDNqQ5dXdX9EXLOoGXA1MW2jdt5Y9PQcmC6Bd6CFG_IivVaNKLT6i1ZgdB9I5kWp-R9zlsAUJyJd-SU91xwrroVuf85PXlMdE7TjKlEzNSOnrppmK0rcRrpbJMdsGDKtGxsoXEMuwVHh3ReRrehuUT3EMf7Q8SYY3mmU6D_brMOlzq2u_yBnIQq-PGoZ-TX9de7q2_N7Y-b71dfbhsnlCxNF4QEJgVIzoVQdq3WNsCaK9vrXngVQIa-40Fb5jUwL_zacRss6KBVJ504I58PufWaPwvmYoaYHe52dsRpyabi4bJnvOuqVR6sLk05JwxmTnGw6dkwMHvGZmuOjM2esQFuKuO69-lYsfwe0P_feoFaDZcHA9ZHHyMmk13cE_MxoSvGT_GVir_oM5Gj</recordid><startdate>20170415</startdate><enddate>20170415</enddate><creator>Paul, Shubhajit</creator><creator>Taylor, Lisa J.</creator><creator>Murphy, Brendan</creator><creator>Krzyzaniak, Joseph F.</creator><creator>Dawson, Neil</creator><creator>Mullarney, Matthew P.</creator><creator>Meenan, Paul</creator><creator>Sun, Changquan Calvin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170415</creationdate><title>Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals</title><author>Paul, Shubhajit ; Taylor, Lisa J. ; Murphy, Brendan ; Krzyzaniak, Joseph F. ; Dawson, Neil ; Mullarney, Matthew P. ; Meenan, Paul ; Sun, Changquan Calvin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-4f3501530522336a969af0926a8783d6f05f842f7a1d701d3d9c2afa07f7645c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Least-Squares Analysis</topic><topic>Linear regression</topic><topic>Particle Size</topic><topic>PLS analysis</topic><topic>Porosity</topic><topic>Powder compaction</topic><topic>Powders</topic><topic>Sticking</topic><topic>Surface area</topic><topic>Surface Properties</topic><topic>Tablets</topic><topic>Technology, Pharmaceutical</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paul, Shubhajit</creatorcontrib><creatorcontrib>Taylor, Lisa J.</creatorcontrib><creatorcontrib>Murphy, Brendan</creatorcontrib><creatorcontrib>Krzyzaniak, Joseph F.</creatorcontrib><creatorcontrib>Dawson, Neil</creatorcontrib><creatorcontrib>Mullarney, Matthew P.</creatorcontrib><creatorcontrib>Meenan, Paul</creatorcontrib><creatorcontrib>Sun, Changquan Calvin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paul, Shubhajit</au><au>Taylor, Lisa J.</au><au>Murphy, Brendan</au><au>Krzyzaniak, Joseph F.</au><au>Dawson, Neil</au><au>Mullarney, Matthew P.</au><au>Meenan, Paul</au><au>Sun, Changquan Calvin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2017-04-15</date><risdate>2017</risdate><volume>521</volume><issue>1-2</issue><spage>374</spage><epage>383</epage><pages>374-383</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is to identify process parameters and particle properties that can profoundly affect sticking performance. This work was aimed at elucidating the key material properties and compaction parameters that influence punch sticking by statistically analyzing punch sticking data of 24 chemically diverse compounds obtained using a set of tooling with removable upper punch tip. Partial least square (PLS) analysis of the data revealed that particle surface area and tablet tensile strength are the most significant factors attributed to punch sticking. Die-wall pressure, ejection force, and take-off force also correlate with sticking, but to a lesser extent.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28232264</pmid><doi>10.1016/j.ijpharm.2017.02.053</doi><tpages>10</tpages></addata></record> |
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| ispartof | International journal of pharmaceutics, 2017-04, Vol.521 (1-2), p.374-383 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Least-Squares Analysis Linear regression Particle Size PLS analysis Porosity Powder compaction Powders Sticking Surface area Surface Properties Tablets Technology, Pharmaceutical Tensile Strength |
| title | Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals |
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