MSMEG_5684 down-regulation in Mycobacterium smegmatis affects its permeability, survival under stress and persistence

Abstract The Mycobacterium tuberculosis ( Mtb ) genome sequence and annotation details have been available for a long time; however physiological relevance of many ORFs remains poorly described. Mtb is a pathogenic strain; hence, surrogate strains such as Mycobacterium bovis BCG and Mycobacterium sm...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2017-03, Vol.103, p.61-70
Hauptverfasser:	Keshari, Deepa, Singh, Kumar Sachin, Sharma, Rishabh, Yadav, Shailendra, Singh, Sudheer Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Annotations Anti-Bacterial Agents - pharmacology Antimycobacterial agents Bacillus Calmette-Guerin vaccine Bacterial Proteins - genetics Bacterial Proteins - metabolism BCG Carbon sources Complementation Detergents - toxicity Down-Regulation E coli Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Genomes Genotype Glycerol Infectious Disease Knockdown Metabolism Microbial Viability Mycobacterium smegmatis Mycobacterium smegmatis - drug effects Mycobacterium smegmatis - genetics Mycobacterium smegmatis - metabolism Mycobacterium smegmatis - pathogenicity Nitric Oxide Donors - toxicity Nucleotide sequence Oxidants - toxicity Oxidative Stress Permeability Persistence Phenotype Phosphoserine aminotransferase Physiology Pulmonary/Respiratory Restoration Serine Strain Stress Stress, Physiological Supplements Survival Time Factors Transaminases - genetics Transaminases - metabolism Transcription Tuberculosis
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