Pulmonary adenocarcinoma with enteric differentiation: Dissecting oncogenic genes alterations with DNA sequencing and FISH analysis

Pulmonary Adenocarcinoma with Enteric Differentiation (PAED) is a rare subtype of adenocarcinoma of emerging interest, recently introduced in the 2015 WHO classification. However, little is known about major molecular signatures of this class of adenocarcinomas and information about new biomarkers t...

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Veröffentlicht in:	Experimental and molecular pathology 2017-04, Vol.102 (2), p.276-279
Hauptverfasser:	Nottegar, Alessia, Tabbò, Fabrizio, Luchini, Claudio, Guerrera, Francesco, Gaudiano, Marcello, Bria, Emilio, Brunelli, Matteo, Chilosi, Marco, Inghirami, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adenocarcinoma of Lung Aged ALK Anaplastic Lymphoma Kinase Class I Phosphatidylinositol 3-Kinases Codon EGFR Enteric ErbB Receptors - genetics ErbB Receptors - metabolism Female Gene Expression Regulation, Neoplastic Gene Rearrangement GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans In Situ Hybridization, Fluorescence K-RAS Lung adenocarcinoma Lung Neoplasms - diagnosis Lung Neoplasms - genetics Male Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Mutation Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PIK3CA Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Sequence Analysis, DNA
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