Inhibition of α‑Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α‑Synuclein Species

The Hsp70 family of chaperones plays an essential role in suppressing protein aggregation in the cell. Here we investigate the factors controlling the intrinsic ability of human Hsp70 to inhibit the elongation of amyloid fibrils formed by the Parkinson’s disease-related protein α-synuclein. Using ki...

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Veröffentlicht in:	Biochemistry (Easton) 2017-03, Vol.56 (9), p.1177-1180
Hauptverfasser:	Aprile, Francesco A, Arosio, Paolo, Fusco, Giuliana, Chen, Serene W, Kumita, Janet R, Dhulesia, Anne, Tortora, Paolo, Knowles, Tuomas P. J, Vendruscolo, Michele, Dobson, Christopher M, Cremades, Nunilo
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - metabolism Binding, Competitive HSP70 Heat-Shock Proteins - metabolism Humans Kinetics Protein Multimerization Protein Structure, Secondary Substrate Specificity
Online-Zugang:	Volltext
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