$Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs$

Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs

As a culinary and medicinal herb, rosemary is widely used. The present work aimed to investigate the effects of rosemary extracts on metabolic diseases and the underlying mechanisms of action. Liver cells stably expressing SREBP reporter were used to evaluate the inhibitory effects of different frac...

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Veröffentlicht in:	Chinese journal of natural medicines 2016-10, Vol.14 (10), p.746-756
Hauptverfasser:	XIE, Zhi-Shen, ZHONG, Ling-Jun, WAN, Xiao-Meng, LI, Meng-Ning, YANG, Hua, LI, Ping, XU, Xiao-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes - chemistry Animals Cholesterol - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Humans Hyperlipidemia Hyperlipidemias - drug therapy Hyperlipidemias - genetics Hyperlipidemias - metabolism Insulin - metabolism Insulin Resistance Liver - drug effects Liver - metabolism Male Mice Mice, Inbred C57BL Petroleum - analysis Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - isolation & purification Rosemary Rosmarinus - chemistry SREBPs Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism
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