OAS Gene Family Expression Is Associated with HIV-Related Neurocognitive Disorders

HIV-associated neurocognitive disorders are common in HIV-infected individuals, even in the combination antiretroviral therapy (c-ART) era. Several mechanisms are involved in neuronal damage, including chronic inflammation immune activation. Mammalian 2′-5′-oligoadenylate synthetase (OAS) genes are...

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Veröffentlicht in:	Molecular neurobiology 2018-03, Vol.55 (3), p.1905-1914
Hauptverfasser:	Sanfilippo, C., Pinzone, M.R., Cambria, D., Longo, A., Palumbo, M., Di Marco, R., Condorelli, F., Nunnari, G., Malaguarnera, L., Di Rosa, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - biosynthesis 2',5'-Oligoadenylate Synthetase - genetics Animals Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Basal ganglia Biomedical and Life Sciences Biomedicine Brain Cell activation Cell Biology Central nervous system Cognition Cortex (frontal) CXCL10 protein Databases, Genetic Dementia disorders DNA microarrays Encephalitis Gene Expression Gene Regulatory Networks - genetics Genes Genetic Association Studies - methods Hippocampus - metabolism HIV HIV Infections - complications HIV Infections - genetics HIV Infections - metabolism Human immunodeficiency virus Humans Immune response Inflammation Interferon Macaca mulatta Male Monocytes Neurobiology Neurocognitive Disorders - etiology Neurocognitive Disorders - genetics Neurocognitive Disorders - metabolism Neurology Neurosciences Ribonuclease L Ribonucleic acid RNA Simian Acquired Immunodeficiency Syndrome - complications Simian Acquired Immunodeficiency Syndrome - genetics Simian Acquired Immunodeficiency Syndrome - metabolism Substantia alba
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