Stigma-related stress, shame and avoidant coping reactions among members of the general population with elevated symptom levels

Abstract Background It is unclear whether mental illness stigma affects individuals with subthreshold syndromes outside clinical settings. We therefore investigated the role of different stigma variables, including stigma-related stress and shame reactions, for avoidant stigma coping among members o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Comprehensive psychiatry 2017-04, Vol.74, p.224-230
Hauptverfasser: Schibalski, J.V, Müller, M, Ajdacic-Gross, V, Vetter, S, Rodgers, S, Oexle, N, Corrigan, P.W, Rössler, W, Rüsch, N
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 230
container_issue
container_start_page 224
container_title Comprehensive psychiatry
container_volume 74
creator Schibalski, J.V
Müller, M
Ajdacic-Gross, V
Vetter, S
Rodgers, S
Oexle, N
Corrigan, P.W
Rössler, W
Rüsch, N
description Abstract Background It is unclear whether mental illness stigma affects individuals with subthreshold syndromes outside clinical settings. We therefore investigated the role of different stigma variables, including stigma-related stress and shame reactions, for avoidant stigma coping among members of the general population with elevated symptom levels. Methods Based on a representative population survey, general stress resilience, stigma variables, shame about having a mental illness as well as avoidant stigma coping (secrecy and social withdrawal) were assessed by self-report among 676 participants with elevated symptom levels. Stigma variables and resilience were examined as predictors of avoidant stigma coping in a path model. Results Increased stigma stress was predicted by lower general stress resilience as well as by higher levels of perceived stigma, group identification and perceived legitimacy of discrimination. More shame was associated with higher perceived legitimacy. Lower resilience as well as more perceived stigma, group identification and perceived legitimacy predicted avoidant coping. Stigma stress partly mediated effects of resilience, perceived stigma and group identification on avoidant coping; shame partly mediated effects of perceived legitimacy on coping. Stigma stress and shame were also directly and positively related to avoidant stigma coping. Analyses were adjusted for symptoms, neuroticism and sociodemographic variables. Conclusions Stigma may affect a larger proportion of the population than previously thought because stigma variables predicted secrecy and withdrawal among members of the general population with elevated, but overall mild symptom levels. Avoidant stigma coping likely has harmful effects, potentially exacerbating pre-existing psychological distress and undermining social networks. This highlights the need to reduce public stigma as well as to support individuals with subthreshold syndromes in their coping with stigma stress and shame reactions.
doi_str_mv 10.1016/j.comppsych.2017.02.001
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1872574959</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0010440X16306046</els_id><sourcerecordid>4320990135</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-8acfb41fb914522c1e30aed60cc04318bdbf0031536ffb0407e9fdd8fd9e4e5d3</originalsourceid><addsrcrecordid>eNqNkk9vEzEQxVcIREPhK4AlLj10w_jP7joXpKqigFSJQ0HiZnnt2cRhvV5sJygnvjqOUorUEydrrN974_GbqnpDYUmBtu-2SxP8PKeD2SwZ0G4JbAlAn1QL2nBWSy7F02pRbqAWAr6fVS9S2gKAlFI8r86YZLztOraoft9lt_a6jjjqjJakHDGlS5I22iPRkyV6H5zVUyYmzG5ak4jaZBemRLQPpfboe4yJhIHkDZI1Thj1SOYw74plAckvlzcER9yfOhz8nIMnpcYxvayeDXpM-Or-PK--3Xz4ev2pvv3y8fP11W1tRCNyLbUZekGHfkVFw5ihyEGjbcEYEJzK3vYDAC_Dt8PQg4AOV4O1crArFNhYfl5dnHznGH7uMGXlXTI4jnrCsEuKyo41nVg1q4K-fYRuwy5O5XVHSsqGccoL1Z0oE0NKEQc1R-d1PCgK6piR2qqHjNQxIwVMlUSK8vW9_673aB90f0MpwNUJKP-De4dRJeNwMmhdRJOVDe4_mrx_5GFGNzmjxx94wPRvIpWKQN0dV-W4KbTl0IJo-R9ofr7t</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1878852313</pqid></control><display><type>article</type><title>Stigma-related stress, shame and avoidant coping reactions among members of the general population with elevated symptom levels</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Schibalski, J.V ; Müller, M ; Ajdacic-Gross, V ; Vetter, S ; Rodgers, S ; Oexle, N ; Corrigan, P.W ; Rössler, W ; Rüsch, N</creator><creatorcontrib>Schibalski, J.V ; Müller, M ; Ajdacic-Gross, V ; Vetter, S ; Rodgers, S ; Oexle, N ; Corrigan, P.W ; Rössler, W ; Rüsch, N</creatorcontrib><description>Abstract Background It is unclear whether mental illness stigma affects individuals with subthreshold syndromes outside clinical settings. We therefore investigated the role of different stigma variables, including stigma-related stress and shame reactions, for avoidant stigma coping among members of the general population with elevated symptom levels. Methods Based on a representative population survey, general stress resilience, stigma variables, shame about having a mental illness as well as avoidant stigma coping (secrecy and social withdrawal) were assessed by self-report among 676 participants with elevated symptom levels. Stigma variables and resilience were examined as predictors of avoidant stigma coping in a path model. Results Increased stigma stress was predicted by lower general stress resilience as well as by higher levels of perceived stigma, group identification and perceived legitimacy of discrimination. More shame was associated with higher perceived legitimacy. Lower resilience as well as more perceived stigma, group identification and perceived legitimacy predicted avoidant coping. Stigma stress partly mediated effects of resilience, perceived stigma and group identification on avoidant coping; shame partly mediated effects of perceived legitimacy on coping. Stigma stress and shame were also directly and positively related to avoidant stigma coping. Analyses were adjusted for symptoms, neuroticism and sociodemographic variables. Conclusions Stigma may affect a larger proportion of the population than previously thought because stigma variables predicted secrecy and withdrawal among members of the general population with elevated, but overall mild symptom levels. Avoidant stigma coping likely has harmful effects, potentially exacerbating pre-existing psychological distress and undermining social networks. This highlights the need to reduce public stigma as well as to support individuals with subthreshold syndromes in their coping with stigma stress and shame reactions.</description><identifier>ISSN: 0010-440X</identifier><identifier>EISSN: 1532-8384</identifier><identifier>DOI: 10.1016/j.comppsych.2017.02.001</identifier><identifier>PMID: 28236772</identifier><identifier>CODEN: COPYAV</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adaptation, Psychological ; Adolescent ; Adult ; Age ; Avoidance Learning ; Coping ; Cross-Sectional Studies ; Female ; Humans ; Identification ; Legitimacy ; Male ; Mental disorders ; Mental Disorders - diagnosis ; Mental Disorders - psychology ; Mental health care ; Middle age ; Middle Aged ; Population Surveillance - methods ; Psychiatry ; Self Concept ; Self Report ; Shame ; Social research ; Social Stigma ; Social Support ; Stereotypes ; Stigma ; Stress ; Stress, Psychological - diagnosis ; Stress, Psychological - psychology ; Studies</subject><ispartof>Comprehensive psychiatry, 2017-04, Vol.74, p.224-230</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 01, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-8acfb41fb914522c1e30aed60cc04318bdbf0031536ffb0407e9fdd8fd9e4e5d3</citedby><cites>FETCH-LOGICAL-c454t-8acfb41fb914522c1e30aed60cc04318bdbf0031536ffb0407e9fdd8fd9e4e5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0010440X16306046$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28236772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schibalski, J.V</creatorcontrib><creatorcontrib>Müller, M</creatorcontrib><creatorcontrib>Ajdacic-Gross, V</creatorcontrib><creatorcontrib>Vetter, S</creatorcontrib><creatorcontrib>Rodgers, S</creatorcontrib><creatorcontrib>Oexle, N</creatorcontrib><creatorcontrib>Corrigan, P.W</creatorcontrib><creatorcontrib>Rössler, W</creatorcontrib><creatorcontrib>Rüsch, N</creatorcontrib><title>Stigma-related stress, shame and avoidant coping reactions among members of the general population with elevated symptom levels</title><title>Comprehensive psychiatry</title><addtitle>Compr Psychiatry</addtitle><description>Abstract Background It is unclear whether mental illness stigma affects individuals with subthreshold syndromes outside clinical settings. We therefore investigated the role of different stigma variables, including stigma-related stress and shame reactions, for avoidant stigma coping among members of the general population with elevated symptom levels. Methods Based on a representative population survey, general stress resilience, stigma variables, shame about having a mental illness as well as avoidant stigma coping (secrecy and social withdrawal) were assessed by self-report among 676 participants with elevated symptom levels. Stigma variables and resilience were examined as predictors of avoidant stigma coping in a path model. Results Increased stigma stress was predicted by lower general stress resilience as well as by higher levels of perceived stigma, group identification and perceived legitimacy of discrimination. More shame was associated with higher perceived legitimacy. Lower resilience as well as more perceived stigma, group identification and perceived legitimacy predicted avoidant coping. Stigma stress partly mediated effects of resilience, perceived stigma and group identification on avoidant coping; shame partly mediated effects of perceived legitimacy on coping. Stigma stress and shame were also directly and positively related to avoidant stigma coping. Analyses were adjusted for symptoms, neuroticism and sociodemographic variables. Conclusions Stigma may affect a larger proportion of the population than previously thought because stigma variables predicted secrecy and withdrawal among members of the general population with elevated, but overall mild symptom levels. Avoidant stigma coping likely has harmful effects, potentially exacerbating pre-existing psychological distress and undermining social networks. This highlights the need to reduce public stigma as well as to support individuals with subthreshold syndromes in their coping with stigma stress and shame reactions.</description><subject>Adaptation, Psychological</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Avoidance Learning</subject><subject>Coping</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Identification</subject><subject>Legitimacy</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Mental Disorders - diagnosis</subject><subject>Mental Disorders - psychology</subject><subject>Mental health care</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Population Surveillance - methods</subject><subject>Psychiatry</subject><subject>Self Concept</subject><subject>Self Report</subject><subject>Shame</subject><subject>Social research</subject><subject>Social Stigma</subject><subject>Social Support</subject><subject>Stereotypes</subject><subject>Stigma</subject><subject>Stress</subject><subject>Stress, Psychological - diagnosis</subject><subject>Stress, Psychological - psychology</subject><subject>Studies</subject><issn>0010-440X</issn><issn>1532-8384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk9vEzEQxVcIREPhK4AlLj10w_jP7joXpKqigFSJQ0HiZnnt2cRhvV5sJygnvjqOUorUEydrrN974_GbqnpDYUmBtu-2SxP8PKeD2SwZ0G4JbAlAn1QL2nBWSy7F02pRbqAWAr6fVS9S2gKAlFI8r86YZLztOraoft9lt_a6jjjqjJakHDGlS5I22iPRkyV6H5zVUyYmzG5ak4jaZBemRLQPpfboe4yJhIHkDZI1Thj1SOYw74plAckvlzcER9yfOhz8nIMnpcYxvayeDXpM-Or-PK--3Xz4ev2pvv3y8fP11W1tRCNyLbUZekGHfkVFw5ihyEGjbcEYEJzK3vYDAC_Dt8PQg4AOV4O1crArFNhYfl5dnHznGH7uMGXlXTI4jnrCsEuKyo41nVg1q4K-fYRuwy5O5XVHSsqGccoL1Z0oE0NKEQc1R-d1PCgK6piR2qqHjNQxIwVMlUSK8vW9_673aB90f0MpwNUJKP-De4dRJeNwMmhdRJOVDe4_mrx_5GFGNzmjxx94wPRvIpWKQN0dV-W4KbTl0IJo-R9ofr7t</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Schibalski, J.V</creator><creator>Müller, M</creator><creator>Ajdacic-Gross, V</creator><creator>Vetter, S</creator><creator>Rodgers, S</creator><creator>Oexle, N</creator><creator>Corrigan, P.W</creator><creator>Rössler, W</creator><creator>Rüsch, N</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Stigma-related stress, shame and avoidant coping reactions among members of the general population with elevated symptom levels</title><author>Schibalski, J.V ; Müller, M ; Ajdacic-Gross, V ; Vetter, S ; Rodgers, S ; Oexle, N ; Corrigan, P.W ; Rössler, W ; Rüsch, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-8acfb41fb914522c1e30aed60cc04318bdbf0031536ffb0407e9fdd8fd9e4e5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptation, Psychological</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Avoidance Learning</topic><topic>Coping</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Identification</topic><topic>Legitimacy</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Mental Disorders - diagnosis</topic><topic>Mental Disorders - psychology</topic><topic>Mental health care</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>Population Surveillance - methods</topic><topic>Psychiatry</topic><topic>Self Concept</topic><topic>Self Report</topic><topic>Shame</topic><topic>Social research</topic><topic>Social Stigma</topic><topic>Social Support</topic><topic>Stereotypes</topic><topic>Stigma</topic><topic>Stress</topic><topic>Stress, Psychological - diagnosis</topic><topic>Stress, Psychological - psychology</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schibalski, J.V</creatorcontrib><creatorcontrib>Müller, M</creatorcontrib><creatorcontrib>Ajdacic-Gross, V</creatorcontrib><creatorcontrib>Vetter, S</creatorcontrib><creatorcontrib>Rodgers, S</creatorcontrib><creatorcontrib>Oexle, N</creatorcontrib><creatorcontrib>Corrigan, P.W</creatorcontrib><creatorcontrib>Rössler, W</creatorcontrib><creatorcontrib>Rüsch, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Comprehensive psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schibalski, J.V</au><au>Müller, M</au><au>Ajdacic-Gross, V</au><au>Vetter, S</au><au>Rodgers, S</au><au>Oexle, N</au><au>Corrigan, P.W</au><au>Rössler, W</au><au>Rüsch, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stigma-related stress, shame and avoidant coping reactions among members of the general population with elevated symptom levels</atitle><jtitle>Comprehensive psychiatry</jtitle><addtitle>Compr Psychiatry</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>74</volume><spage>224</spage><epage>230</epage><pages>224-230</pages><issn>0010-440X</issn><eissn>1532-8384</eissn><coden>COPYAV</coden><abstract>Abstract Background It is unclear whether mental illness stigma affects individuals with subthreshold syndromes outside clinical settings. We therefore investigated the role of different stigma variables, including stigma-related stress and shame reactions, for avoidant stigma coping among members of the general population with elevated symptom levels. Methods Based on a representative population survey, general stress resilience, stigma variables, shame about having a mental illness as well as avoidant stigma coping (secrecy and social withdrawal) were assessed by self-report among 676 participants with elevated symptom levels. Stigma variables and resilience were examined as predictors of avoidant stigma coping in a path model. Results Increased stigma stress was predicted by lower general stress resilience as well as by higher levels of perceived stigma, group identification and perceived legitimacy of discrimination. More shame was associated with higher perceived legitimacy. Lower resilience as well as more perceived stigma, group identification and perceived legitimacy predicted avoidant coping. Stigma stress partly mediated effects of resilience, perceived stigma and group identification on avoidant coping; shame partly mediated effects of perceived legitimacy on coping. Stigma stress and shame were also directly and positively related to avoidant stigma coping. Analyses were adjusted for symptoms, neuroticism and sociodemographic variables. Conclusions Stigma may affect a larger proportion of the population than previously thought because stigma variables predicted secrecy and withdrawal among members of the general population with elevated, but overall mild symptom levels. Avoidant stigma coping likely has harmful effects, potentially exacerbating pre-existing psychological distress and undermining social networks. This highlights the need to reduce public stigma as well as to support individuals with subthreshold syndromes in their coping with stigma stress and shame reactions.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28236772</pmid><doi>10.1016/j.comppsych.2017.02.001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0010-440X
ispartof Comprehensive psychiatry, 2017-04, Vol.74, p.224-230
issn 0010-440X
1532-8384
language eng
recordid cdi_proquest_miscellaneous_1872574959
source MEDLINE; Elsevier ScienceDirect Journals
subjects Adaptation, Psychological
Adolescent
Adult
Age
Avoidance Learning
Coping
Cross-Sectional Studies
Female
Humans
Identification
Legitimacy
Male
Mental disorders
Mental Disorders - diagnosis
Mental Disorders - psychology
Mental health care
Middle age
Middle Aged
Population Surveillance - methods
Psychiatry
Self Concept
Self Report
Shame
Social research
Social Stigma
Social Support
Stereotypes
Stigma
Stress
Stress, Psychological - diagnosis
Stress, Psychological - psychology
Studies
title Stigma-related stress, shame and avoidant coping reactions among members of the general population with elevated symptom levels
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T08%3A11%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stigma-related%20stress,%20shame%20and%20avoidant%20coping%20reactions%20among%20members%20of%20the%20general%20population%20with%20elevated%20symptom%20levels&rft.jtitle=Comprehensive%20psychiatry&rft.au=Schibalski,%20J.V&rft.date=2017-04-01&rft.volume=74&rft.spage=224&rft.epage=230&rft.pages=224-230&rft.issn=0010-440X&rft.eissn=1532-8384&rft.coden=COPYAV&rft_id=info:doi/10.1016/j.comppsych.2017.02.001&rft_dat=%3Cproquest_cross%3E4320990135%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1878852313&rft_id=info:pmid/28236772&rft_els_id=S0010440X16306046&rfr_iscdi=true