Comparative pharmacokinetics of bergenin, a main active constituent of Saxifraga stolonifera Curt., in normal and hepatic injury rats after oral administration

Bergenin, isolated from the herb of Saxifrage stoloniJera Curt. （Hu-Er-Cao） has hepatoprotective, anti-inflammatory, antitussive, and neuroprotective activities. The aim of the present study was to establish a simple, rapid, and sensitive RP-HPLC method for determination of bergenin in rat plasma an...

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Veröffentlicht in:	Chinese journal of natural medicines 2016-10, Vol.14 (10), p.776-782
Hauptverfasser:	PAN, Rong-Hua, HE, Hong-Mei, DAI, Yue, XIA, Yu-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzopyrans - administration & dosage Benzopyrans - pharmacokinetics Bergenin Carbon Tetrachloride Chemical and Drug Induced Liver Injury - drug therapy Chromatography, High Pressure Liquid Chromatography, Liquid Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacokinetics Hepatic injury HPLC Humans Male Pharmacokinetic Rats Rats, Sprague-Dawley Saxifragaceae - chemistry Saxifrage stolonifera Curt Tandem Mass Spectrometry - methods
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