Analysis of ribosyl-modified, mixed backbone analogs of a bcl-2/bcl-xL antisense oligonucleotide

Progress in oligonucleotide chemistry has provided second-generation antisense oligonucleotides with increased efficacy and reduced non-antisense-related toxicity. The ability of the 2′- O-(2-methoxyethylribose) (2′-MOE)-modified phosphorothioate gapmer oligonucleotide 4625, which matches the bcl-2...

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