Essential role of Fc gamma receptors in anti-type II collagen antibody-induced arthritis

Anti-type II collagen (anti-CII) Ab is a well-known autoantibody observed in patients with rheumatoid arthritis. Injection of anti-CII Ab and LPS induces arthritis in mice in which anti-CII Ab as well as inflammatory cytokines, IL-1beta and TNF-alpha, play critical roles. We investigated the involve...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-04, Vol.170 (8), p.4318-4324
Hauptverfasser:	Kagari, Takashi, Tanaka, Daisuke, Doi, Hiromi, Shimozato, Takaichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - immunology Animals Antigens, CD - genetics Antigens, CD - metabolism Arthritis, Experimental - genetics Arthritis, Experimental - immunology Arthritis, Experimental - metabolism Arthritis, Experimental - prevention & control Autoantibodies - administration & dosage Autoantibodies - metabolism Autoantibodies - toxicity Binding Sites, Antibody - genetics Binding Sites, Antibody - immunology Cartilage, Articular - immunology Cartilage, Articular - metabolism Collagen Type II - immunology Complement C3 - metabolism Drug Combinations Immunoglobulin Fab Fragments - administration & dosage Injections, Intravenous Interleukin-1 - biosynthesis Lipopolysaccharides - administration & dosage Male Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Protein Binding - genetics Protein Binding - immunology Receptors, IgG - deficiency Receptors, IgG - genetics Receptors, IgG - metabolism Receptors, IgG - physiology Tumor Necrosis Factor-alpha - biosynthesis
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