Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway

Interleukin-6 (IL-6) has received particular attention in the pathogenesis of cervical cancer, although the underlying mechanism remains elusive. This study revealed that IL-6 promotes in vivo tumor growth of human cervical cancer C33A cells, but does not substantially alter their in vitro growth ki...

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Veröffentlicht in:	Oncogene 2003-03, Vol.22 (10), p.1517-1527
Hauptverfasser:	Wei, Lin-Hung, Kuo, Min-Liang, Chen, Chi-An, Chou, Chia-Hung, Lai, Kuo-Bau, Lee, Chien-Nan, Hsieh, Chang-Yao
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Angiogenesis Animals Antibodies, Monoclonal - pharmacology Apoptosis Biological and medical sciences Carcinogenicity Tests Care and treatment Causes of Cell Biology Cell Division - genetics Cervical cancer Cervix Cervix Uteri - metabolism Chick Embryo Culture Media, Conditioned - pharmacology Cytokines DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endothelial Growth Factors - genetics Endothelial Growth Factors - metabolism Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Genetic aspects Gynecology Health aspects Human Genetics Human papillomavirus Humans Hypoxia Immune system Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Interleukin 6 Interleukin-6 - physiology Internal Medicine Kinases Lymphokines - drug effects Lymphokines - genetics Lymphokines - metabolism MAP kinase Medical schools Medicine Medicine & Public Health Mice Mice, Nude Molecular and cellular biology Neovascularization Neovascularization, Pathologic Obstetrics Oncology original-paper Pathogenesis Physiology Reference Values Risk factors Signal Transduction Stat3 protein STAT3 Transcription Factor Toxicology Trans-Activators - genetics Trans-Activators - metabolism Transcription Transfection Tumor Cells, Cultured Tumorigenesis Up-Regulation Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Women
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