Adenovirus E1A, not human papillomavirus E7, sensitizes tumor cells to lysis by macrophages through nitric oxide- and TNF-alpha-dependent mechanisms despite up-regulation of 70-kDa heat shock protein

Expression of adenovirus (Ad) serotype 2 or 5 (Ad2/5) E1A or human papillomavirus (HPV)16 E7 reportedly sensitizes cells to lysis by macrophages. Macrophages possess several mechanisms to kill tumor cells including TNF-alpha, NO, reactive oxygen intermediates (ROI), and Fas ligand (FasL). E1A sensit...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-04, Vol.170 (8), p.4119-4126
Hauptverfasser:	Miura, Tanya A, Morris, Kristin, Ryan, Sharon, Cook, James L, Routes, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adenovirus E1A Proteins - biosynthesis Adenovirus E1A Proteins - immunology Adenoviruses, Human - immunology Animals Cell Line, Transformed Cytotoxicity Tests, Immunologic - methods Fas Ligand Protein fas Receptor - metabolism HSP70 Heat-Shock Proteins - biosynthesis HSP70 Heat-Shock Proteins - physiology Humans Immunization Ligands Macrophage Activation - immunology Macrophages - immunology Macrophages - metabolism Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Nitric Oxide - toxicity Oncogene Proteins, Viral - immunology Papillomavirus E7 Proteins Sarcoma, Experimental - immunology Sarcoma, Experimental - prevention & control Sarcoma, Experimental - virology Superoxides - metabolism Tumor Cells, Cultured Tumor Necrosis Factor-alpha - toxicity Up-Regulation - immunology
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