Thymic Epithelial Cells

Intrathymic T cell development is a complex process that depends upon continuous guidance from thymus stromal cell microenvironments. The thymic epithelium within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenotypic, and functional heterogeneity. These prop...

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Veröffentlicht in:	Annual review of immunology 2017-04, Vol.35 (1), p.85-118
Hauptverfasser:	Abramson, Jakub, Anderson, Graham
Format:	Artikel
Sprache:	eng
Schlagworte:	Aire AIRE Protein Animals Autoimmunity Cell Differentiation Epithelial Cells - immunology Epithelial Cells - metabolism Forkhead Transcription Factors - metabolism Foxp3 Humans Immune Tolerance T cell T-Lymphocytes - physiology thymic epithelium thymus Thymus Gland - immunology Thymus Gland - pathology tolerance Transcription Factors - metabolism
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