Foetal Protection against Bovine Virus Diarrhoea Virus after Two-step Vaccination
Summary In order to assess the efficacy of a two‐step vaccination protocol with respect to foetal protection against transplacental infections with bovine virus diarrhoea virus (BVDV) with special attention to BVDV‐2 seronegative heifers were vaccinated with an inactivated BVDV‐1 vaccine and booster...
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| Veröffentlicht in: | Journal of veterinary medicine. Series B 2002-12, Vol.49 (10), p.489-493 |
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| container_title | Journal of veterinary medicine. Series B |
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| creator | Frey, H.-R. Eicken, K. Grummer, B. Kenklies, S. Oguzoglu, T. C. Moennig, V. |
| description | Summary
In order to assess the efficacy of a two‐step vaccination protocol with respect to foetal protection against transplacental infections with bovine virus diarrhoea virus (BVDV) with special attention to BVDV‐2 seronegative heifers were vaccinated with an inactivated BVDV‐1 vaccine and boostered with a modified live BVDV‐1 vaccine after 4 weeks. A second group was left unvaccinated as control. Between days 30 and 120 of pregnancy the heifers of both groups were intranasally challenged with a mixture of BVDV‐1 and ‐2. All heifers of the vaccinated group gave birth to nine clinically healthy, seronegative (precolostral) and BVDV‐free calves. In contrast in the control group four BVDV viraemic underdeveloped calves were born. Additionally, one calf was stillborn and another viraemic calf was not viable and died 2 days after birth. All six calves of the control group were viraemic with BVDV‐2.
This study demonstrated for the first time that two‐step vaccination of breeding cattle with a modified live BVDV vaccine 4 weeks after application of an inactivated BVDV vaccine was capable of providing a foetal protection against transplacental infection with BVDV‐2. |
| doi_str_mv | 10.1046/j.1439-0450.2002.00599.x |
| format | Article |
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In order to assess the efficacy of a two‐step vaccination protocol with respect to foetal protection against transplacental infections with bovine virus diarrhoea virus (BVDV) with special attention to BVDV‐2 seronegative heifers were vaccinated with an inactivated BVDV‐1 vaccine and boostered with a modified live BVDV‐1 vaccine after 4 weeks. A second group was left unvaccinated as control. Between days 30 and 120 of pregnancy the heifers of both groups were intranasally challenged with a mixture of BVDV‐1 and ‐2. All heifers of the vaccinated group gave birth to nine clinically healthy, seronegative (precolostral) and BVDV‐free calves. In contrast in the control group four BVDV viraemic underdeveloped calves were born. Additionally, one calf was stillborn and another viraemic calf was not viable and died 2 days after birth. All six calves of the control group were viraemic with BVDV‐2.
This study demonstrated for the first time that two‐step vaccination of breeding cattle with a modified live BVDV vaccine 4 weeks after application of an inactivated BVDV vaccine was capable of providing a foetal protection against transplacental infection with BVDV‐2.</description><identifier>ISSN: 0931-1793</identifier><identifier>EISSN: 1439-0450</identifier><identifier>DOI: 10.1046/j.1439-0450.2002.00599.x</identifier><identifier>PMID: 12485359</identifier><language>eng</language><publisher>Berlin, Germany: Blackwell Verlag GmbH</publisher><subject>Animals ; Antibodies, Viral - genetics ; Antibodies, Viral - isolation & purification ; Bovine Virus Diarrhea-Mucosal Disease - prevention & control ; Bovine Virus Diarrhea-Mucosal Disease - transmission ; Bovine Virus Diarrhea-Mucosal Disease - virology ; Cattle ; Diarrhea Virus 1, Bovine Viral - immunology ; Diarrhea Virus 1, Bovine Viral - pathogenicity ; Diarrhea Virus 2, Bovine Viral - immunology ; Diarrhea Virus 2, Bovine Viral - pathogenicity ; Drug Administration Schedule ; Female ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious Disease Transmission, Vertical - veterinary ; Injections, Subcutaneous - veterinary ; Neutralization Tests - veterinary ; Pregnancy ; Pregnancy Complications, Infectious - prevention & control ; Pregnancy Complications, Infectious - veterinary ; Vaccination ; Vaccines, Inactivated ; Viral Vaccines</subject><ispartof>Journal of veterinary medicine. Series B, 2002-12, Vol.49 (10), p.489-493</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4029-2765068cbf362ffa82f21bfa5ee5ab24f55933bc9d59b978ece36143a70ac2803</citedby><cites>FETCH-LOGICAL-c4029-2765068cbf362ffa82f21bfa5ee5ab24f55933bc9d59b978ece36143a70ac2803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1439-0450.2002.00599.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1439-0450.2002.00599.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12485359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frey, H.-R.</creatorcontrib><creatorcontrib>Eicken, K.</creatorcontrib><creatorcontrib>Grummer, B.</creatorcontrib><creatorcontrib>Kenklies, S.</creatorcontrib><creatorcontrib>Oguzoglu, T. C.</creatorcontrib><creatorcontrib>Moennig, V.</creatorcontrib><title>Foetal Protection against Bovine Virus Diarrhoea Virus after Two-step Vaccination</title><title>Journal of veterinary medicine. Series B</title><addtitle>J Vet Med B Infect Dis Vet Public Health</addtitle><description>Summary
In order to assess the efficacy of a two‐step vaccination protocol with respect to foetal protection against transplacental infections with bovine virus diarrhoea virus (BVDV) with special attention to BVDV‐2 seronegative heifers were vaccinated with an inactivated BVDV‐1 vaccine and boostered with a modified live BVDV‐1 vaccine after 4 weeks. A second group was left unvaccinated as control. Between days 30 and 120 of pregnancy the heifers of both groups were intranasally challenged with a mixture of BVDV‐1 and ‐2. All heifers of the vaccinated group gave birth to nine clinically healthy, seronegative (precolostral) and BVDV‐free calves. In contrast in the control group four BVDV viraemic underdeveloped calves were born. Additionally, one calf was stillborn and another viraemic calf was not viable and died 2 days after birth. All six calves of the control group were viraemic with BVDV‐2.
This study demonstrated for the first time that two‐step vaccination of breeding cattle with a modified live BVDV vaccine 4 weeks after application of an inactivated BVDV vaccine was capable of providing a foetal protection against transplacental infection with BVDV‐2.</description><subject>Animals</subject><subject>Antibodies, Viral - genetics</subject><subject>Antibodies, Viral - isolation & purification</subject><subject>Bovine Virus Diarrhea-Mucosal Disease - prevention & control</subject><subject>Bovine Virus Diarrhea-Mucosal Disease - transmission</subject><subject>Bovine Virus Diarrhea-Mucosal Disease - virology</subject><subject>Cattle</subject><subject>Diarrhea Virus 1, Bovine Viral - immunology</subject><subject>Diarrhea Virus 1, Bovine Viral - pathogenicity</subject><subject>Diarrhea Virus 2, Bovine Viral - immunology</subject><subject>Diarrhea Virus 2, Bovine Viral - pathogenicity</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Infectious Disease Transmission, Vertical - veterinary</subject><subject>Injections, Subcutaneous - veterinary</subject><subject>Neutralization Tests - veterinary</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - prevention & control</subject><subject>Pregnancy Complications, Infectious - veterinary</subject><subject>Vaccination</subject><subject>Vaccines, Inactivated</subject><subject>Viral Vaccines</subject><issn>0931-1793</issn><issn>1439-0450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFO3DAQQC1UBCvKL1Q5cUs6tuMklri02wKVUEtVCoiLNTFjMM3GWztblr9v0l3RKyfb8ntj-TGWcSg4lNX7x4KXUudQKigEgCgAlNbFeofNXi7esBloyXNea7nPDlPyLYyoUAB6j-1zUTZKKj1j308CDdhlFzEMZAcf-gzv0fdpyD6GP76n7MrHVco-eYzxIRBuz-gGitnlU8jTQMvsCq31PU7-W7brsEt0uF0P2M-Tz5fzs_z82-mX-Yfz3JYgdC7qSkHV2NbJSjiHjXCCtw4VkcJWlE4pLWVr9Z3Sra4bsiSr8X9YA1rRgDxgR5u5yxh-rygNZuGTpa7DnsIqGd7UUw4-gs0GtDGkFMmZZfQLjM-Gg5mKmkczkWYKZ6ai5l9Rsx7Vd9s3Vu2C7v6L234jcLwBnnxHz68ebG4vzsbNqOcb3Y8V1y86xl-mqmWtzPXXUzMX1zfqZn5rfsi_UIGTvw</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Frey, H.-R.</creator><creator>Eicken, K.</creator><creator>Grummer, B.</creator><creator>Kenklies, S.</creator><creator>Oguzoglu, T. C.</creator><creator>Moennig, V.</creator><general>Blackwell Verlag GmbH</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>200212</creationdate><title>Foetal Protection against Bovine Virus Diarrhoea Virus after Two-step Vaccination</title><author>Frey, H.-R. ; Eicken, K. ; Grummer, B. ; Kenklies, S. ; Oguzoglu, T. C. ; Moennig, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4029-2765068cbf362ffa82f21bfa5ee5ab24f55933bc9d59b978ece36143a70ac2803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antibodies, Viral - genetics</topic><topic>Antibodies, Viral - isolation & purification</topic><topic>Bovine Virus Diarrhea-Mucosal Disease - prevention & control</topic><topic>Bovine Virus Diarrhea-Mucosal Disease - transmission</topic><topic>Bovine Virus Diarrhea-Mucosal Disease - virology</topic><topic>Cattle</topic><topic>Diarrhea Virus 1, Bovine Viral - immunology</topic><topic>Diarrhea Virus 1, Bovine Viral - pathogenicity</topic><topic>Diarrhea Virus 2, Bovine Viral - immunology</topic><topic>Diarrhea Virus 2, Bovine Viral - pathogenicity</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Infectious Disease Transmission, Vertical - prevention & control</topic><topic>Infectious Disease Transmission, Vertical - veterinary</topic><topic>Injections, Subcutaneous - veterinary</topic><topic>Neutralization Tests - veterinary</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - prevention & control</topic><topic>Pregnancy Complications, Infectious - veterinary</topic><topic>Vaccination</topic><topic>Vaccines, Inactivated</topic><topic>Viral Vaccines</topic><toplevel>online_resources</toplevel><creatorcontrib>Frey, H.-R.</creatorcontrib><creatorcontrib>Eicken, K.</creatorcontrib><creatorcontrib>Grummer, B.</creatorcontrib><creatorcontrib>Kenklies, S.</creatorcontrib><creatorcontrib>Oguzoglu, T. C.</creatorcontrib><creatorcontrib>Moennig, V.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of veterinary medicine. Series B</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frey, H.-R.</au><au>Eicken, K.</au><au>Grummer, B.</au><au>Kenklies, S.</au><au>Oguzoglu, T. C.</au><au>Moennig, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Foetal Protection against Bovine Virus Diarrhoea Virus after Two-step Vaccination</atitle><jtitle>Journal of veterinary medicine. Series B</jtitle><addtitle>J Vet Med B Infect Dis Vet Public Health</addtitle><date>2002-12</date><risdate>2002</risdate><volume>49</volume><issue>10</issue><spage>489</spage><epage>493</epage><pages>489-493</pages><issn>0931-1793</issn><eissn>1439-0450</eissn><abstract>Summary
In order to assess the efficacy of a two‐step vaccination protocol with respect to foetal protection against transplacental infections with bovine virus diarrhoea virus (BVDV) with special attention to BVDV‐2 seronegative heifers were vaccinated with an inactivated BVDV‐1 vaccine and boostered with a modified live BVDV‐1 vaccine after 4 weeks. A second group was left unvaccinated as control. Between days 30 and 120 of pregnancy the heifers of both groups were intranasally challenged with a mixture of BVDV‐1 and ‐2. All heifers of the vaccinated group gave birth to nine clinically healthy, seronegative (precolostral) and BVDV‐free calves. In contrast in the control group four BVDV viraemic underdeveloped calves were born. Additionally, one calf was stillborn and another viraemic calf was not viable and died 2 days after birth. All six calves of the control group were viraemic with BVDV‐2.
This study demonstrated for the first time that two‐step vaccination of breeding cattle with a modified live BVDV vaccine 4 weeks after application of an inactivated BVDV vaccine was capable of providing a foetal protection against transplacental infection with BVDV‐2.</abstract><cop>Berlin, Germany</cop><pub>Blackwell Verlag GmbH</pub><pmid>12485359</pmid><doi>10.1046/j.1439-0450.2002.00599.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Antibodies, Viral - genetics Antibodies, Viral - isolation & purification Bovine Virus Diarrhea-Mucosal Disease - prevention & control Bovine Virus Diarrhea-Mucosal Disease - transmission Bovine Virus Diarrhea-Mucosal Disease - virology Cattle Diarrhea Virus 1, Bovine Viral - immunology Diarrhea Virus 1, Bovine Viral - pathogenicity Diarrhea Virus 2, Bovine Viral - immunology Diarrhea Virus 2, Bovine Viral - pathogenicity Drug Administration Schedule Female Infectious Disease Transmission, Vertical - prevention & control Infectious Disease Transmission, Vertical - veterinary Injections, Subcutaneous - veterinary Neutralization Tests - veterinary Pregnancy Pregnancy Complications, Infectious - prevention & control Pregnancy Complications, Infectious - veterinary Vaccination Vaccines, Inactivated Viral Vaccines |
| title | Foetal Protection against Bovine Virus Diarrhoea Virus after Two-step Vaccination |
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