Doxorubicin-Dependent Reduction of Ferrylmyoglobin and Inhibition of Lipid Peroxidation: Implications for Cardiotoxicity of Anticancer Anthracyclines

Lipid peroxidation has been proposed to mediate cardiotoxicity induced by doxorubicin (DOX) and other anticancer anthracyclines; however, there have been reports showing that DOX can also inhibit lipid peroxidation. Here we characterized the effects of DOX on the oxo-ferryl moiety [FeIVO, MbIV] of...

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Veröffentlicht in:	Chemical research in toxicology 2002-09, Vol.15 (9), p.1179-1189
Hauptverfasser:	Menna, Pierantonio, Salvatorelli, Emanuela, Giampietro, Rossella, Liberi, Giovanni, Teodori, Giovanni, Calafiore, Antonio M, Minotti, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - toxicity Arachidonic Acid - metabolism Doxorubicin - analogs & derivatives Doxorubicin - pharmacology Doxorubicin - toxicity ferrylmyoglobin Free Radicals Heart - drug effects Horses Humans Hydrogen Peroxide - metabolism Inhibitory Concentration 50 Iron - metabolism Kinetics Lipid Peroxidation - drug effects Metmyoglobin - chemistry Metmyoglobin - metabolism Myocardium - metabolism Oxidation-Reduction - drug effects Statistics as Topic
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