The performance of the mSEPT9 assay is influenced by algorithm, cancer stage and age, but not sex and cancer location

Purpose This study aims to examine the influence of algorithm and subject-related factors, including cancer stage, age, sex, and cancer location, on the performance of the SEPT9 gene methylation test, an assay approved by the US FDA for colorectal cancer (CRC) screening. Methods A total of 1225 subj...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2017-06, Vol.143 (6), p.1093-1101
Hauptverfasser:	Song, Lele, Jia, Jia, Yu, Haotian, Peng, Xiumei, Xiao, Wenhua, Gong, Yuan, Zhou, Guangpeng, Han, Xiaoliang, Li, Yuemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Adenoma - diagnosis Adenoma - pathology Adult Age Age Factors Aged Aged, 80 and over Algorithms Bioassays Cancer Cancer Research Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Methylation Early Detection of Cancer - methods Female Hematology Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Neoplasm Staging Oncology Original Article – Clinical Oncology Polymerase Chain Reaction Polyps Reproducibility of Results Sensitivity and Specificity Septins - genetics Sex Sex Factors Tumors
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