Protein Kinase CK2 Phosphorylates the High Mobility Group Domain Protein SSRP1, Inducing the Recognition of UV-damaged DNA

The structure-specific recognition protein SSRP1 plays a role in transcription and replication in the chromatin context. Mediated by its C-terminal high mobility group (HMG) box domain, SSRP1 binds DNA non-sequence specifically but recognizes certain DNA structures. Using acetic acid urea polyacryla...

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Veröffentlicht in:	The Journal of biological chemistry 2003-04, Vol.278 (15), p.12710-12715
Hauptverfasser:	Krohn, Nicholas M, Stemmer, Christian, Fojan, Peter, Grimm, Rudi, Grasser, Klaus D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Base Sequence Casein Kinase II Circular Dichroism DNA - metabolism DNA - radiation effects DNA Damage DNA Primers DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism High Mobility Group Proteins - chemistry High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Humans Kinetics Phosphorylation Plant Proteins - genetics Plant Proteins - metabolism Protein Conformation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Recombinant Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Transcriptional Elongation Factors Ultraviolet Rays Zea mays - metabolism
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