Effects of inactivation and constitutive expression of the unfolded-protein response pathway on protein production in the yeast Saccharomyces cerevisiae

One strategy to obtain better yields of secreted proteins has been overexpression of single endoplasmic reticulum-resident foldases or chaperones. We report here that manipulation of the unfolded-protein response (UPR) pathway regulator, HAC1, affects production of both native and foreign proteins i...

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Veröffentlicht in:	Applied and Environmental Microbiology 2003-04, Vol.69 (4), p.2065-2072
Hauptverfasser:	Valkonen, M, Penttila, M, Saloheimo, M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-amylase alpha-Amylases - genetics alpha-Amylases - metabolism Bacillus - enzymology Bacillus - genetics Bacillus amyloliquefaciens Basic-Leucine Zipper Transcription Factors beta-fructofuranosidase Biological and medical sciences Cellulase - genetics Cellulase - metabolism endo-1,4-beta-glucanase Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics Fungal Proteins - metabolism Gene Deletion gene expression Gene Expression Regulation, Fungal gene overexpression gene transfer genes genetically engineered microorganisms HAC1 gene Hypocrea jecorina Microbiology mutants Physiology and Biotechnology Protein Folding protein secretion protein synthesis recombinant proteins Repressor Proteins - genetics Repressor Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism transcription factors Transcription Factors - genetics Transcription Factors - metabolism Trichoderma - genetics Trichoderma - metabolism Yeast yeasts
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