Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

Pseudomonas aeruginosa infection is a serious complication in patients with cystic fibrosis and in immunocompromised individuals. Here we show that P. aeruginosa infection triggers activation of the acid sphingomyelinase and the release of ceramide in sphingolipid-rich rafts. Ceramide reorganizes th...

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Veröffentlicht in:	Nature medicine 2003-03, Vol.9 (3), p.322-330
Hauptverfasser:	Gulbins, E, Grassmé, H, Jendrossek, V, Riehle, A, von Kürthy, G, Berger, J, Schwarz, H, Weller, M, Kolesnick, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology beta-Cyclodextrins Biomedical and Life Sciences Biomedicine Bone Marrow Transplantation Cancer Research Cells, Cultured Ceramides - metabolism Cyclodextrins - pharmacology Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Enzyme Activation Epithelial Cells - drug effects Epithelial Cells - metabolism fas Receptor - metabolism Fibroblasts - drug effects Fibroblasts - physiology Filipin - pharmacology Fluorescent Dyes - metabolism Humans Infectious Diseases Ionophores - pharmacology Membrane Microdomains - chemistry Membrane Microdomains - immunology Membrane Microdomains - metabolism Membranes Metabolic Diseases Mice Molecular Medicine Neurosciences Nystatin - pharmacology Pathogens Pseudomonas aeruginosa - physiology Pseudomonas Infections - immunology Pseudomonas Infections - metabolism Signal Transduction - physiology Sphingomyelin Phosphodiesterase - genetics Sphingomyelin Phosphodiesterase - metabolism
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