Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX

MSH2 and MLH1 have a central role in correcting mismatches in DNA occurring during DNA replication and have been implicated in the engagement of apoptosis induced by a number of cytotoxic anticancer agents. The function of MLH1 is not clearly defined, although it is required for mismatch repair (MMR...

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Veröffentlicht in:	Oncogene 2003-02, Vol.22 (6), p.819-825
Hauptverfasser:	Partlin, Mary Mac, Homer, Elizabeth, Robinson, Helen, J McCormick, Carol, Crouch, Dorothy H, Durant, Stephen T, Matheson, Elizabeth C, Hall, Andrew G, Gillespie, David AF, Brown, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino acids Animals Antitumor agents Apoptosis Base Pair Mismatch Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors Biological and medical sciences Breast c-Myc protein Cancer research Carrier Proteins Cell Biology Cell cycle Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytotoxicity Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA repair DNA Repair - physiology DNA-Binding Proteins - metabolism Frameshift mutation Fundamental and applied biological sciences. Psychology Fusion protein Human Genetics Humans Hypoxanthine Phosphoribosyltransferase - genetics Internal Medicine Laboratories Medical research Medicine Medicine & Public Health Mismatch repair MLH1 protein MMR protein Molecular and cellular biology MSH2 protein Mutagenesis - physiology Mutation Mutation rates MutL Protein Homolog 1 MutS Homolog 2 Protein Myc protein Neoplasm Proteins - metabolism Nuclear Proteins Oncology original-paper Ovaries Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Rats Transcription Factors Tumor Cells, Cultured Tumors Two-Hybrid System Techniques Yeast
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