Ir-Catalyzed Asymmetric Total Synthesis of (−)-Communesin F

The first catalytic asymmetric total synthesis of the heptacyclic alkaloid (−)-communesin F is described. A key step features an iridium-catalyzed asymmetric intermolecular cascade cyclization, constructing the lower N,N-aminal-containing CDEF tetracyclic core in one step. Another notable element is...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-03, Vol.139 (9), p.3364-3367
Hauptverfasser:	Liang, Xiao, Zhang, Tian-Yuan, Zeng, Xue-Yi, Zheng, Yu, Wei, Kun, Yang, Yu-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Crystallography, X-Ray Cyclization Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Iridium - chemistry Models, Molecular Molecular Structure Stereoisomerism
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