The Role of Exosomes in Cancer Metastasis

Abstract Exosomes are small membrane vesicles with a size ranging from 40–100 nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of t...

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Veröffentlicht in:	Seminars in cancer biology 2017-06, Vol.44, p.170-181
Hauptverfasser:	Steinbichler, Teresa Bernadette, Dudás, József, Riechelmann, Herbert, Skvortsova, Ira-Ida
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer-associated fibroblasts EMT Exosomes - genetics Exosomes - pathology Hematology, Oncology and Palliative Medicine Humans Liquid Biopsy Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplasms - genetics Neoplasms - pathology Organotropic metastasis Premetastatic niche Tumor derived exosomes Tumor Microenvironment - genetics
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Zusammenfassung:	Abstract Exosomes are small membrane vesicles with a size ranging from 40–100 nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes influence every step of this cascade and can be targeted by oncological treatment. This review highlights the role of exosomes in the various steps of the metastatic cascade and how exosome dependent pathways can be targeted as therapeutic approach or used for liquid biopsies.
ISSN:	1044-579X 1096-3650
DOI:	10.1016/j.semcancer.2017.02.006