Evaluation of a combinational use of serum microRNAs as biomarkers for liver diseases
Summary Circulating microRNAs (miRNA) have been widely recognized as a novel noninvasive biomarker in a variety of physiological and pathological conditions. In order to assess the sensitivity and reliability of potential miRNAs as diagnostic markers for liver disease related to viral infection, alc...
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| Veröffentlicht in: | Clinics and research in hepatology and gastroenterology 2017-06, Vol.41 (3), p.254-261 |
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| container_title | Clinics and research in hepatology and gastroenterology |
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| creator | Xu, Ping Guo, Anliang Xu, Junchi Yao, Jianer Chen, Hui Wang, Fengping Zhu, Chuanwu |
| description | Summary Circulating microRNAs (miRNA) have been widely recognized as a novel noninvasive biomarker in a variety of physiological and pathological conditions. In order to assess the sensitivity and reliability of potential miRNAs as diagnostic markers for liver disease related to viral infection, alcohol abuse, or chemical exposure, we collected serum samples from 326 participants and evaluated the single and combination diagnostic values of three serum miRNAs (miR-122, miR-125b, miR-192) compared with a conventional marker ALT. We found that serum miR-122 is significantly elevated in patients with active HBV. MiR-125b increased in HCV positive patients, whereas miR-192 and miR-122 were associated with chemical-induced liver injury. None of the aforementioned miRNAs were shown to increase significantly in alcohol-related liver injuries. Furthermore, we analyzed different combinations and found that a set of miR-122 and miR-125b enhanced the sensitivity of detecting liver injury. Among the 58 ALI/ALF patients, miR-122 responded more rapidly than ALT in successful treatments. Patients with spontaneous recovery from ALI/ALF showed significantly higher serum levels of miR-122 and miR-125b compared to non-recovered patients. In conclusion, our results suggest that the combination of miR-122 and miR-125b may serve as efficient biomarkers for liver injury and may be of a prognostic value in predicting ALI/ALF outcome. |
| doi_str_mv | 10.1016/j.clinre.2016.10.013 |
| format | Article |
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In order to assess the sensitivity and reliability of potential miRNAs as diagnostic markers for liver disease related to viral infection, alcohol abuse, or chemical exposure, we collected serum samples from 326 participants and evaluated the single and combination diagnostic values of three serum miRNAs (miR-122, miR-125b, miR-192) compared with a conventional marker ALT. We found that serum miR-122 is significantly elevated in patients with active HBV. MiR-125b increased in HCV positive patients, whereas miR-192 and miR-122 were associated with chemical-induced liver injury. None of the aforementioned miRNAs were shown to increase significantly in alcohol-related liver injuries. Furthermore, we analyzed different combinations and found that a set of miR-122 and miR-125b enhanced the sensitivity of detecting liver injury. Among the 58 ALI/ALF patients, miR-122 responded more rapidly than ALT in successful treatments. Patients with spontaneous recovery from ALI/ALF showed significantly higher serum levels of miR-122 and miR-125b compared to non-recovered patients. In conclusion, our results suggest that the combination of miR-122 and miR-125b may serve as efficient biomarkers for liver injury and may be of a prognostic value in predicting ALI/ALF outcome.</description><identifier>ISSN: 2210-7401</identifier><identifier>EISSN: 2210-741X</identifier><identifier>DOI: 10.1016/j.clinre.2016.10.013</identifier><identifier>PMID: 28215541</identifier><language>eng</language><publisher>France</publisher><subject>Biomarkers - blood ; Gastroenterology and Hepatology ; Humans ; Internal Medicine ; Liver Diseases - blood ; Liver Diseases - diagnosis ; MicroRNAs - genetics ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Sensitivity and Specificity</subject><ispartof>Clinics and research in hepatology and gastroenterology, 2017-06, Vol.41 (3), p.254-261</ispartof><rights>Elsevier Masson SAS</rights><rights>Copyright © 2017 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-505c99cd670a94514f35d303e5fd955bca97f0c06ab2d6af54c5ea6cd58b030f3</citedby><cites>FETCH-LOGICAL-c362t-505c99cd670a94514f35d303e5fd955bca97f0c06ab2d6af54c5ea6cd58b030f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28215541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Ping</creatorcontrib><creatorcontrib>Guo, Anliang</creatorcontrib><creatorcontrib>Xu, Junchi</creatorcontrib><creatorcontrib>Yao, Jianer</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Wang, Fengping</creatorcontrib><creatorcontrib>Zhu, Chuanwu</creatorcontrib><title>Evaluation of a combinational use of serum microRNAs as biomarkers for liver diseases</title><title>Clinics and research in hepatology and gastroenterology</title><addtitle>Clin Res Hepatol Gastroenterol</addtitle><description>Summary Circulating microRNAs (miRNA) have been widely recognized as a novel noninvasive biomarker in a variety of physiological and pathological conditions. In order to assess the sensitivity and reliability of potential miRNAs as diagnostic markers for liver disease related to viral infection, alcohol abuse, or chemical exposure, we collected serum samples from 326 participants and evaluated the single and combination diagnostic values of three serum miRNAs (miR-122, miR-125b, miR-192) compared with a conventional marker ALT. We found that serum miR-122 is significantly elevated in patients with active HBV. MiR-125b increased in HCV positive patients, whereas miR-192 and miR-122 were associated with chemical-induced liver injury. None of the aforementioned miRNAs were shown to increase significantly in alcohol-related liver injuries. Furthermore, we analyzed different combinations and found that a set of miR-122 and miR-125b enhanced the sensitivity of detecting liver injury. Among the 58 ALI/ALF patients, miR-122 responded more rapidly than ALT in successful treatments. Patients with spontaneous recovery from ALI/ALF showed significantly higher serum levels of miR-122 and miR-125b compared to non-recovered patients. In conclusion, our results suggest that the combination of miR-122 and miR-125b may serve as efficient biomarkers for liver injury and may be of a prognostic value in predicting ALI/ALF outcome.</description><subject>Biomarkers - blood</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Liver Diseases - blood</subject><subject>Liver Diseases - diagnosis</subject><subject>MicroRNAs - genetics</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><issn>2210-7401</issn><issn>2210-741X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU9LxDAQxYMoKrrfQCRHL7tOmqTdXgQR_4EoqAveQppOIGu70cx2wW9v6qq5JHm8ecn8hrETATMBojxfzlwXVglnRb5laQZC7rDDohAwrZR42_0_gzhgE6Il5KU0zCuxzw6KeSG0VuKQLa43thvsOsQVj55b7mLfhNWPYDs-EI4yYRp63geX4vPjJXFLvAmxt-kdE3EfE-_CBhNvA6ElpGO2521HOPndj9ji5vr16m768HR7f3X5MHWyLNZTDdrVtWvLCmyttFBe6laCRO3bWuvG2bry4KC0TdGW1mvlNNrStXregAQvj9jZNvcjxc8BaW36QA67zq4wDmTEvIJSjcnZqrbW3ANRQm8-UsgdfBkBZmRqlmbL1IxMRzUzzWWnvy8MTY_tf9EfwWy42Bow97kJmH5SgrPdO34hLeOQMsj8FUOFAfMyjmWciqgkgAAlvwFp4Iks</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Xu, Ping</creator><creator>Guo, Anliang</creator><creator>Xu, Junchi</creator><creator>Yao, Jianer</creator><creator>Chen, Hui</creator><creator>Wang, Fengping</creator><creator>Zhu, Chuanwu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Evaluation of a combinational use of serum microRNAs as biomarkers for liver diseases</title><author>Xu, Ping ; Guo, Anliang ; Xu, Junchi ; Yao, Jianer ; Chen, Hui ; Wang, Fengping ; Zhu, Chuanwu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-505c99cd670a94514f35d303e5fd955bca97f0c06ab2d6af54c5ea6cd58b030f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomarkers - blood</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Liver Diseases - blood</topic><topic>Liver Diseases - diagnosis</topic><topic>MicroRNAs - genetics</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Ping</creatorcontrib><creatorcontrib>Guo, Anliang</creatorcontrib><creatorcontrib>Xu, Junchi</creatorcontrib><creatorcontrib>Yao, Jianer</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Wang, Fengping</creatorcontrib><creatorcontrib>Zhu, Chuanwu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinics and research in hepatology and gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Ping</au><au>Guo, Anliang</au><au>Xu, Junchi</au><au>Yao, Jianer</au><au>Chen, Hui</au><au>Wang, Fengping</au><au>Zhu, Chuanwu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a combinational use of serum microRNAs as biomarkers for liver diseases</atitle><jtitle>Clinics and research in hepatology and gastroenterology</jtitle><addtitle>Clin Res Hepatol Gastroenterol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>41</volume><issue>3</issue><spage>254</spage><epage>261</epage><pages>254-261</pages><issn>2210-7401</issn><eissn>2210-741X</eissn><abstract>Summary Circulating microRNAs (miRNA) have been widely recognized as a novel noninvasive biomarker in a variety of physiological and pathological conditions. In order to assess the sensitivity and reliability of potential miRNAs as diagnostic markers for liver disease related to viral infection, alcohol abuse, or chemical exposure, we collected serum samples from 326 participants and evaluated the single and combination diagnostic values of three serum miRNAs (miR-122, miR-125b, miR-192) compared with a conventional marker ALT. We found that serum miR-122 is significantly elevated in patients with active HBV. MiR-125b increased in HCV positive patients, whereas miR-192 and miR-122 were associated with chemical-induced liver injury. None of the aforementioned miRNAs were shown to increase significantly in alcohol-related liver injuries. Furthermore, we analyzed different combinations and found that a set of miR-122 and miR-125b enhanced the sensitivity of detecting liver injury. Among the 58 ALI/ALF patients, miR-122 responded more rapidly than ALT in successful treatments. Patients with spontaneous recovery from ALI/ALF showed significantly higher serum levels of miR-122 and miR-125b compared to non-recovered patients. In conclusion, our results suggest that the combination of miR-122 and miR-125b may serve as efficient biomarkers for liver injury and may be of a prognostic value in predicting ALI/ALF outcome.</abstract><cop>France</cop><pmid>28215541</pmid><doi>10.1016/j.clinre.2016.10.013</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biomarkers - blood Gastroenterology and Hepatology Humans Internal Medicine Liver Diseases - blood Liver Diseases - diagnosis MicroRNAs - genetics Predictive Value of Tests Prognosis Risk Factors Sensitivity and Specificity |
| title | Evaluation of a combinational use of serum microRNAs as biomarkers for liver diseases |
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