Endothelial Cells Inhibit the Angiotensin II Induced Phenotypic Modulation of Rat Vascular Adventitial Fibroblasts

ABSTRACT The phenotypic modulation of vascular adventitial fibroblasts plays an important role in vascular remodeling. Evidence have shown that endothelial cells and adventitial fibroblasts interact under certain conditions. In this study, we investigated the influence of endothelial cells on the ph...

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Veröffentlicht in:	Journal of cellular biochemistry 2017-07, Vol.118 (7), p.1921-1927
Hauptverfasser:	Xu, Jia‐Ying, Chang, Neng‐Bin, Li, Tao, Jiang, Rui, Sun, Xiao‐Lei, He, Yan‐Zheng, Jiang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Adventitia - cytology Angiotensin Angiotensin II ANGIOTENSIN II (ANG II) Angiotensin II - pharmacology Animals Aorta Aorta, Thoracic - cytology Arginine Arginine - pharmacology Cell culture Cells, Cultured Circulatory system Coculture Techniques Collagen Collagen (type I) Collagen Type I - metabolism Cyclic GMP Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology ENDOTHELIAL CELLS Endothelial Cells - drug effects Endothelial Cells - metabolism Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Genetic transformation Homocysteine Homocysteine - pharmacology Modulation NG-Nitroarginine methyl ester NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide PHENOTYPIC MODULATION Rats Rats, Sprague-Dawley Rodents Signal transduction Signal Transduction - drug effects Smooth muscle Supplements Thorax VASCULAR ADVENTITIAL FIBROBLASTS
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