Role of FOXP3 gene polymorphism in the susceptibility to Tunisian endemic Pemphigus Foliaceus

Highlights • FOXP3 gene polymorphism is implicated in the susceptibility to Tunisian Pemphigus Foliaceus. • FOXP3 gene distributions are significantly different between endemic and sporadic forms. • FOXP3 gene intervenes mainly in the occurrence and clinical presentation of the endemic form. • Addit...

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Veröffentlicht in:	Immunology letters 2017-04, Vol.184, p.105-111
Hauptverfasser:	Ben Jmaa, Mariem, Abida, Olfa, Bahloul, Emna, Toumi, Amina, Khlif, Sana, Fakhfakh, Raouia, Elloumi, Nesrine, Sellami, Khadija, Masmoudi, Abderrahmen, Turki, Hamida, Masmoudi, Hatem
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alleles Allergy and Immunology Autoimmunity Case-Control Studies Female Forkhead Transcription Factors - genetics FOXP3 Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Haplotypes Humans Immunogenetics Linkage Disequilibrium Male Middle Aged Pemphigus - genetics Pemphigus - immunology Pemphigus foliaceus Polymorphism Polymorphism, Single Nucleotide Regulatory T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tunisia Young Adult
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Zusammenfassung:	Highlights • FOXP3 gene polymorphism is implicated in the susceptibility to Tunisian Pemphigus Foliaceus. • FOXP3 gene distributions are significantly different between endemic and sporadic forms. • FOXP3 gene intervenes mainly in the occurrence and clinical presentation of the endemic form. • Additional argument to the particular genetic background of the Tunisian endemic P F.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2017.02.005