The N-terminal region of organic anion transporting polypeptide 1B3 (OATP1B3) plays an essential role in regulating its plasma membrane trafficking

[Display omitted] Organic anion transporting polypeptide 1B3 (OATP1B3) is a major influx transporter mediating the hepatic uptake of various endogenous substrates as well as clinically important drugs such as statins and anticancer drugs. However, molecular mechanisms controlling the membrane traffi...

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Veröffentlicht in:	Biochemical pharmacology 2017-05, Vol.131, p.98-105
Hauptverfasser:	Chun, Se-Eun, Thakkar, Nilay, Oh, Yunseok, Park, Ji Eun, Han, Songhee, Ryoo, Gongmi, Hahn, Hyunggu, Maeng, Sang Hyun, Lim, Young-Ran, Han, Byung Woo, Lee, Wooin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Cell Membrane - metabolism Humans Membrane trafficking Mice N-terminal region OATP OATP1B3 Organic Anion Transporters, Sodium-Independent - chemistry Organic Anion Transporters, Sodium-Independent - genetics Organic Anion Transporters, Sodium-Independent - physiology Phosphorylation Point Mutation Protein Transport Rats Sequence Homology, Amino Acid Solute Carrier Organic Anion Transporter Family Member 1B3 Subcellular Fractions - metabolism Transporter
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