Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists

[Display omitted] In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the discovery of 23, a highly potent,...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2017-03, Vol.27 (6), p.1364-1370
Hauptverfasser:	Skudlarek, Jason W., DiMarco, Christina N., Babaoglu, Kerim, Roecker, Anthony J., Bruno, Joseph G., Pausch, Mark A., O'Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Wuelfing, W. Peter, Garson, Susan L., Fox, Steven V., Savitz, Alan T., Harrell, Charles M., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Kuduk, Scott D., Coleman, Paul J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonist Electroencephalography Electromyography GPCR Insomnia Molecular Structure Orexin Orexin Receptor Antagonists - chemistry Orexin Receptor Antagonists - pharmacology Orexins - antagonists & inhibitors Rats Sleep
Online-Zugang:	Volltext
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