Differential Regulation of CXCR4-mediated T-cell Chemotaxis and Mitogen-activated Protein Kinase Activation by the Membrane Tyrosine Phosphatase, CD45

The chemokine receptor CXCR4 and its cognate ligand, stromal cell-derived factor-1Î± (CXCL12), regulate lymphocyte trafficking and play an important role in host immune surveillance. However, the molecular mechanisms involved in CXCL12-induced and CXCR4-mediated chemotaxis of T-lymphocytes are not c...

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Veröffentlicht in:	The Journal of biological chemistry 2003-03, Vol.278 (11), p.9536-9543
Hauptverfasser:	Fernandis, Aaron Z, Cherla, Rama P, Ganju, Ramesh K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Blotting, Western Cell Line Chemokine CXCL12 Chemokines, CXC - metabolism Chemotaxis Dose-Response Relationship, Drug Enzyme Activation Flow Cytometry Gene Expression Regulation Humans Jurkat Cells Leukocyte Common Antigens - metabolism Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Lymphocytes - metabolism MAP Kinase Signaling System Microscopy, Confocal Microscopy, Fluorescence Phosphoproteins - metabolism Phosphorylation Precipitin Tests Protein Structure, Tertiary Protein-Tyrosine Kinases - metabolism Receptors, Antigen, T-Cell - metabolism Receptors, CXCR4 - metabolism Signal Transduction T-Lymphocytes - metabolism Time Factors Tyrosine - metabolism ZAP-70 Protein-Tyrosine Kinase
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