Dose‐dependent protective effect of selenium in rat model of Parkinson's disease: neurobehavioral and neurochemical evidences

Normal cellular metabolism produces oxidants that are neutralized within cells by antioxidant enzymes and other antioxidants. An imbalance between oxidant and antioxidant has been postulated to lead the degeneration of dopaminergic neurons in Parkinson's disease. In this study, we examined whet...

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Veröffentlicht in:	Journal of neurochemistry 2003-02, Vol.84 (3), p.438-446
Hauptverfasser:	Zafar, Khan Shoeb, Siddiqui, Almas, Sayeed, Iqbal, Ahmad, Muzamil, Salim, Sofian, Islam, Fakhrul
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism 6‐hydroxydopamine Animals Antioxidants - metabolism Ascorbic Acid - administration & dosage Ascorbic Acid - metabolism Behavior, Animal - drug effects Biological and medical sciences Brain - drug effects Brain - metabolism Brain - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Dopamine - metabolism Dose-Response Relationship, Drug Drug Administration Routes Drug Administration Schedule Glutathione - metabolism Homovanillic Acid - metabolism Lipid Peroxidation - drug effects Male Medical sciences Motor Activity - drug effects Neurology neuroprotection Neuroprotective Agents - administration & dosage Neuroprotective Agents - therapeutic use oxidative stress Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - physiopathology Parkinsonian Disorders - prevention & control Rats Rats, Wistar Recovery of Function selenium Sodium Selenite - administration & dosage Sodium Selenite - therapeutic use Treatment Outcome
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