Amyloid β peptide induces cytochrome c release from isolated mitochondria

Amyloid β peptide (Aβ) is a neurotoxic metabolic product of the amyloid precursor protein (APP). Aβ is strongly implicated in the pathology of Alzheimerʼs disease (AD) and can be formed intracellularly. In this study, we show that the addition of Aβ1-42 to isolated mouse brain mitochondria can direc...

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Veröffentlicht in:	Neuroreport 2002-10, Vol.13 (15), p.1989-1993
Hauptverfasser:	Kim, Hye-Sun, Lee, Jun-Ho, Lee, Jean-Pyo, Kim, Eun-Mee, Chang, Keun-A, Park, Cheol Hyoung, Jeong, Sung-Jin, Wittendorp, M. C, Seo, Ji-Heui, Choi, Se-Hoon, Suh, Yoo-Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - enzymology Alzheimer Disease - physiopathology Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - toxicity Animals Apoptosis - drug effects Apoptosis - physiology Biochemistry and metabolism Biological and medical sciences Brain - drug effects Brain - enzymology Calcium Signaling - drug effects Calcium Signaling - physiology Caspase 3 Caspases - drug effects Caspases - metabolism Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Cells, Cultured Central nervous system Cyclosporine - pharmacology Cytochrome c Group - drug effects Cytochrome c Group - metabolism Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Humans Mice Mitochondria - drug effects Mitochondria - enzymology Neurons - drug effects Neurons - enzymology Peptide Fragments - antagonists & inhibitors Peptide Fragments - metabolism Peptide Fragments - toxicity Vertebrates: nervous system and sense organs
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