Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3

On human macrophages IL-10 acts as a more potent anti-inflammatory cytokine than IL-6, although both cytokines signal mainly via activation of the transcription factor STAT3. In this study we compare IL-10 and IL-6 signaling in primary human macrophages derived from blood monocytes. Pretreatment of...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-03, Vol.170 (6), p.3263-3272
Hauptverfasser:	Niemand, Claudia, Nimmesgern, Ariane, Haan, Serge, Fischer, Patrick, Schaper, Fred, Rossaint, Rolf, Heinrich, Peter C, Muller-Newen, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cells, Cultured DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Enzyme Activation - immunology Enzyme Inhibitors - pharmacology Feedback, Physiological - immunology Humans Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - pharmacology Interleukin-10 - antagonists & inhibitors Interleukin-10 - pharmacology Interleukin-10 - physiology Interleukin-6 - antagonists & inhibitors Interleukin-6 - physiology Intracellular Signaling Peptides and Proteins Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Macrophages - enzymology Macrophages - immunology Macrophages - metabolism MAP Kinase Signaling System - immunology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Protein Biosynthesis Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatases - metabolism Proteins - physiology Repressor Proteins Signal Transduction - drug effects Signal Transduction - immunology STAT3 Transcription Factor Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Tetradecanoylphorbol Acetate - pharmacology Trans-Activators - antagonists & inhibitors Trans-Activators - metabolism Trans-Activators - physiology Transcription Factors Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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