Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes
[Display omitted] Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, alter...
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| Veröffentlicht in: | Pharmacological research 2017-05, Vol.119, p.278-288 |
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| container_title | Pharmacological research |
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| creator | Tu, Yan Johnstone, Cameron N. Stewart, Alastair G. |
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Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting. |
| doi_str_mv | 10.1016/j.phrs.2017.02.011 |
| format | Article |
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Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2017.02.011</identifier><identifier>PMID: 28212890</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adaptive Immunity ; Animals ; Annexin A1 ; Annexin A1 - analysis ; Annexin A1 - genetics ; Annexin A1 - immunology ; Annexin A1 - metabolism ; Breast - immunology ; Breast - metabolism ; Breast - pathology ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - immunology ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cancer immunoediting ; Cell Movement ; Epithelial-Mesenchymal Transition ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunity, Cellular ; Immunity, Innate ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - immunology ; Neoplasm Invasiveness - pathology ; Tumor Microenvironment ; Tumour microenvironment ; Tumour stroma</subject><ispartof>Pharmacological research, 2017-05, Vol.119, p.278-288</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-4f004e28db19bc5d35eb620fd89660f161da171704724b812d26545f1273d8be3</citedby><cites>FETCH-LOGICAL-c271t-4f004e28db19bc5d35eb620fd89660f161da171704724b812d26545f1273d8be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043661816313330$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28212890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tu, Yan</creatorcontrib><creatorcontrib>Johnstone, Cameron N.</creatorcontrib><creatorcontrib>Stewart, Alastair G.</creatorcontrib><title>Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>[Display omitted]
Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting.</description><subject>Adaptive Immunity</subject><subject>Animals</subject><subject>Annexin A1</subject><subject>Annexin A1 - analysis</subject><subject>Annexin A1 - genetics</subject><subject>Annexin A1 - immunology</subject><subject>Annexin A1 - metabolism</subject><subject>Breast - immunology</subject><subject>Breast - metabolism</subject><subject>Breast - pathology</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer immunoediting</subject><subject>Cell Movement</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunity, Innate</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Invasiveness - immunology</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Tumor Microenvironment</subject><subject>Tumour microenvironment</subject><subject>Tumour stroma</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQha2qqFDaP9BD5WMPJMx4s46DelmtaEFC4tKercSeFK829tZ2EPx7HC302NOMZt57o_kY-4JQI6C83NWHh5hqAdjWIGpAfMfOEDpZISr5fumbVSUlqlP2MaUdAHQNwgd2KpRAoTo4Y3HjPT05zzfInR_3M3lDqbR8iNSnzE1fBvGKb4PPMTxSTK7sg-dmGbhhzi74xHPgeZ7CHC_4Qyi23lvupmn2gazLzv_hhxhKcqL0iZ2M_T7R59d6zn7_uP61vanu7n_ebjd3lREt5qoZARoSyg7YDWZtV2sapIDRqk5KGFGi7bHFFppWNINCYYVcN-sRRbuyaqDVOft2zC2X_86Usp5cMrTf957CnHRh1HVSNSCKVBylJoaUIo36EN3Ux2eNoBfWeqcX1nphrUHowrqYvr7mz8NE9p_lDW4RfD8KqHz56CjqZNzC17pIJmsb3P_yXwD7EZFA</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Tu, Yan</creator><creator>Johnstone, Cameron N.</creator><creator>Stewart, Alastair G.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes</title><author>Tu, Yan ; Johnstone, Cameron N. ; Stewart, Alastair G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-4f004e28db19bc5d35eb620fd89660f161da171704724b812d26545f1273d8be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptive Immunity</topic><topic>Animals</topic><topic>Annexin A1</topic><topic>Annexin A1 - analysis</topic><topic>Annexin A1 - genetics</topic><topic>Annexin A1 - immunology</topic><topic>Annexin A1 - metabolism</topic><topic>Breast - immunology</topic><topic>Breast - metabolism</topic><topic>Breast - pathology</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - immunology</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer immunoediting</topic><topic>Cell Movement</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunity, Innate</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasm Invasiveness - immunology</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Tumor Microenvironment</topic><topic>Tumour microenvironment</topic><topic>Tumour stroma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tu, Yan</creatorcontrib><creatorcontrib>Johnstone, Cameron N.</creatorcontrib><creatorcontrib>Stewart, Alastair G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tu, Yan</au><au>Johnstone, Cameron N.</au><au>Stewart, Alastair G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2017-05</date><risdate>2017</risdate><volume>119</volume><spage>278</spage><epage>288</epage><pages>278-288</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>[Display omitted]
Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>28212890</pmid><doi>10.1016/j.phrs.2017.02.011</doi><tpages>11</tpages></addata></record> |
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| subjects | Adaptive Immunity Animals Annexin A1 Annexin A1 - analysis Annexin A1 - genetics Annexin A1 - immunology Annexin A1 - metabolism Breast - immunology Breast - metabolism Breast - pathology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer immunoediting Cell Movement Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic Humans Immunity, Cellular Immunity, Innate Neoplasm Invasiveness - genetics Neoplasm Invasiveness - immunology Neoplasm Invasiveness - pathology Tumor Microenvironment Tumour microenvironment Tumour stroma |
| title | Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes |
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