Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis

Metastasis is the leading cause of breast cancer mortality. Previous studies have implicated hypoxia-induced changes in the composition and stiffness of the extracellular matrix (ECM) in the metastatic process. Therefore, the contribution of potential ECM-binding receptors in this process was explor...

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Veröffentlicht in:	Molecular cancer research 2017-06, Vol.15 (6), p.723-734
Hauptverfasser:	Ju, Julia A., Godet, Inês, Ye, I Chae, Byun, Jungmin, Jayatilaka, Hasini, Lee, Sun Joo, Xiang, Lisha, Samanta, Debangshu, Lee, Meng Horng, Wu, Pei-Hsun, Wirtz, Denis, Semenza, Gregg L., Gilkes, Daniele M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Breast cancer Cancer Clinical trials Collagen Extracellular matrix Fibronectin Hypoxia Hypoxia-inducible factor 1 Hypoxia-inducible factors Integrins Lungs Lymph nodes Mammography Medical research Metastases Metastasis Mortality Receptors Stiffness Tumor cell lines Tumors
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