A Novel Antioxidant and Antiapoptotic Role of Omeprazole to Block Gastric Ulcer through Scavenging of Hydroxyl Radical

The mechanism of the antiulcer effect of omeprazole was studied placing emphasis on its role to block oxidative damage and apoptosis during ulceration. Dose-response studies on gastroprotection in stress and indomethacin-induced ulcer and inhibition of pylorus ligation-induced acid secretion indicat...

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Veröffentlicht in:	The Journal of biological chemistry 2003-03, Vol.278 (13), p.10993-11001
Hauptverfasser:	Biswas, Kaushik, Bandyopadhyay, Uday, Chattopadhyay, Ishita, Varadaraj, Archana, Ali, Esahak, Banerjee, Ranajit K
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles Animals Antioxidants - pharmacology Apoptosis - drug effects DNA Damage Free Radical Scavengers - pharmacology Hydroxyl Radical - metabolism Lansoprazole Omeprazole - analogs & derivatives Omeprazole - pharmacology Oxidation-Reduction Rats Rats, Sprague-Dawley Spectrometry, Mass, Electrospray Ionization Stomach Ulcer - metabolism Stomach Ulcer - pathology Stomach Ulcer - prevention & control
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