A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes

T lymphocytes with unusually high expression of the voltage-gated Kv1.3 channel (Kv1.3 high cells) have been implicated in the pathogenesis of experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis. We have developed a fluoresceinated analog of ShK (ShK-F6CA), the most pot...

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Veröffentlicht in:	The Journal of biological chemistry 2003-03, Vol.278 (11), p.9928-9937
Hauptverfasser:	Beeton, Christine, Wulff, Heike, Singh, Satendra, Botsko, Steve, Crossley, George, Gutman, George A, Cahalan, Michael D, Pennington, Michael, Chandy, K George
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Animals Antigens - biosynthesis Biotin - pharmacology Calcium - metabolism Cell Line Cell Nucleus - metabolism Cnidarian Venoms - pharmacology Dose-Response Relationship, Drug Electrophysiology Flow Cytometry Fluoresceins - pharmacology Fluorescent Dyes - pharmacology Guinea Pigs Humans Kinetics Kv1.3 Potassium Channel Lymphocytes - metabolism Magnetic Resonance Spectroscopy Mice Models, Molecular Peptides - chemistry Potassium Channels - biosynthesis Potassium Channels - chemistry Potassium Channels, Voltage-Gated Protein Kinase C - metabolism Rats Rats, Inbred Lew T-Lymphocytes - metabolism Time Factors Tissue Distribution Up-Regulation
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