Nucleotide Selectivity at a Preinsertion Checkpoint of T7 RNA Polymerase Transcription Elongation

Nucleotide selection is crucial for transcription fidelity control, in particular, for viral T7 RNA polymerase (RNAP) lack of proofreading activity. It has been recognized that multiple kinetic checkpoints exist prior to full nucleotide incorporation. In this work, we implemented intensive atomistic...

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Veröffentlicht in:	The journal of physical chemistry. B 2017-04, Vol.121 (15), p.3777-3786
Hauptverfasser:	E, Chao, Duan, Baogen, Yu, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA-Directed RNA Polymerases - metabolism Molecular Dynamics Simulation Nucleotides - chemistry Nucleotides - metabolism Thermodynamics Transcription Elongation, Genetic Viral Proteins - metabolism
Online-Zugang:	Volltext
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