Improving the Catalytic Performance of (S)‑Proline as Organocatalyst in Asymmetric Aldol Reactions in the Presence of Solvate Ionic Liquids: Involvement of a Supramolecular Aggregate
For the first time, a highly efficient and stereoselective asymmetric aldol reaction employing (S)-proline in the presence of solvate ionic liquids is reported. The reaction seems to proceed via a supramolecular aggregate of (S)-proline, the solvate ionic liquid, and water, affording high yields and...
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| Veröffentlicht in: | Organic letters 2017-03, Vol.19 (5), p.1108-1111 |
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| container_title | Organic letters |
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| creator | Obregón-Zúñiga, Arturo Milán, Mario Juaristi, Eusebio |
| description | For the first time, a highly efficient and stereoselective asymmetric aldol reaction employing (S)-proline in the presence of solvate ionic liquids is reported. The reaction seems to proceed via a supramolecular aggregate of (S)-proline, the solvate ionic liquid, and water, affording high yields and excellent stereoselectivities with low catalyst loadings. |
| doi_str_mv | 10.1021/acs.orglett.7b00129 |
| format | Article |
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| source | American Chemical Society Journals |
| title | Improving the Catalytic Performance of (S)‑Proline as Organocatalyst in Asymmetric Aldol Reactions in the Presence of Solvate Ionic Liquids: Involvement of a Supramolecular Aggregate |
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