ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia

There is no effective therapy for intracerebral hemorrhage (ICH) because of poor understanding of the mechanisms of brain injury after hemorrhage. The NLRP3 inflammasome, as a vital component of innate immune system, which is associated with a wide range of human CNS disorders, including ICH. But it...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-04, Vol.485 (2), p.499-505
Hauptverfasser:	Ye, Xinchun, Zuo, Dandan, Yu, Lu, Zhang, Liang, Tang, Jiao, Cui, Chengcheng, Bao, Lei, Zan, Kun, Zhang, Zuohui, Yang, Xinxin, Chen, Hao, Tang, Hai, Zu, Jie, Shi, Hongjuan, Cui, Guiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Blotting, Western Carrier Proteins - metabolism Caspase 3 - metabolism Cell Line Flow Cytometry Free Radical Scavengers - pharmacology ICH Inflammasomes - drug effects Inflammasomes - metabolism Mice Microglia - cytology Microglia - drug effects Microglia - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism ROS/TXNIP pathway Signal Transduction - drug effects Thioredoxins - metabolism Thrombin Thrombin - pharmacology Time Factors
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