Alterations in hypothalamic–pituitary–adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic ‘binge’ cocaine and withdrawal

Tolerance to the stimulatory effects of cocaine on the hypothalamic–pituitary–adrenal (HPA) axis develops after chronic ‘binge’ cocaine exposure in the rat. This blunting of HPA axis activity in response to cocaine is associated with a cocaine-induced reduction of corticotropin-releasing hormone (CR...

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Veröffentlicht in:	Brain research 2003-02, Vol.964 (2), p.187-199
Hauptverfasser:	Zhou, Yan, Spangler, Rudolph, Schlussman, Stefan D, Ho, Ann, Kreek, Mary Jeanne
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenocorticotropic Hormone - metabolism Amygdala - drug effects Amygdala - metabolism Animals Anterior pituitary Biological and medical sciences Blotting, Northern Chronic ‘binge’ cocaine Cocaine - administration & dosage Cocaine - pharmacology Cocaine withdrawal Corticosterone Corticosterone - metabolism Corticotropin-Releasing Hormone - drug effects Corticotropin-Releasing Hormone - metabolism CRH-R1 Dopamine Uptake Inhibitors - administration & dosage Dopamine Uptake Inhibitors - pharmacology Enkephalins - metabolism Frontal Lobe - drug effects Frontal Lobe - metabolism Hypothalamic–pituitary–adrenal axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Pituitary Gland - drug effects Pituitary Gland - metabolism Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism POMC Pro-Opiomelanocortin - drug effects Pro-Opiomelanocortin - metabolism Protein Precursors - metabolism Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Radioimmunoassay Rats Rats, Inbred F344 Receptors, Corticotropin-Releasing Hormone - drug effects Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - metabolism RNA, Messenger - metabolism Substance Withdrawal Syndrome - metabolism Time Factors
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