Hemin-Stimulated Docking of Cytochrome c to a Hemin−DNA Aptamer Complex

DNA aptamers were selected for their ability to bind simultaneously to the protein cytochrome c and to the metalloporphyrin hemin. Such aptamers each contained a conserved guanine-rich core, analogous to sequences shown previously to form a hemin-binding site when folded. The detailed study of CH6A,...

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Veröffentlicht in:	Biochemistry (Easton) 2002-04, Vol.41 (16), p.5202-5212
Hauptverfasser:	Chinnapen, Daniel J. F, Sen, Dipankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Binding Sites - genetics Cytochrome c Group - chemistry Cytochrome c Group - genetics Cytochrome c Group - metabolism Diethyl Pyrocarbonate - chemistry DNA - chemistry DNA - metabolism G-Quadruplexes Hemin - chemistry Hemin - metabolism Horses Molecular Sequence Data Nucleic Acid Conformation Oligonucleotides - chemistry Oligonucleotides - metabolism Protein Binding - genetics Sequence Deletion Spectrophotometry, Ultraviolet Sulfuric Acid Esters - chemistry
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