TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine

T H 17 cells are major drivers of inflammation and involved in several autoimmune diseases. Tissue inflammation is a beneficial host response to infection, but it can also contribute to autoimmunity. The crosstalk between a tissue and the immune system during an inflammatory response is key for pres...

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Veröffentlicht in:Mucosal immunology 2017-11, Vol.10 (6), p.1431-1442
Hauptverfasser: Pascual-Reguant, A, Bayat Sarmadi, J, Baumann, C, Noster, R, Cirera-Salinas, D, Curato, C, Pelczar, P, Huber, S, Zielinski, C E, Löhning, M, Hauser, A E, Esplugues, E
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container_end_page 1442
container_issue 6
container_start_page 1431
container_title Mucosal immunology
container_volume 10
creator Pascual-Reguant, A
Bayat Sarmadi, J
Baumann, C
Noster, R
Cirera-Salinas, D
Curato, C
Pelczar, P
Huber, S
Zielinski, C E
Löhning, M
Hauser, A E
Esplugues, E
description T H 17 cells are major drivers of inflammation and involved in several autoimmune diseases. Tissue inflammation is a beneficial host response to infection, but it can also contribute to autoimmunity. The crosstalk between a tissue and the immune system during an inflammatory response is key for preserving tissue integrity and restoring physiological processes. However, how the inflamed tissue regulates the magnitude of an immune response by controlling pro-inflammatory T cells is not well characterized so far. Here we show that T H 17 cells accumulating in the small intestine upon inflammation express the IL-33 receptor (ST2) and intestinal epithelial cells (IEC) are the main source of the alarmin interleukin-33 (IL-33). We show that pro-inflammatory T H 17 cells acquire a regulatory phenotype with immunosuppressive properties in response to IL-33. Absence of ST2 signaling promotes the secretion of pro-inflammatory cytokines by T H 17 cells and dampens the secretion of IL-10. Our results provide new insights into the mechanisms by which IEC, via IL-33/ST2 axis, may control pro-inflammatory T H 17 cells in the small intestine to sustain homeostasis.
doi_str_mv 10.1038/mi.2017.5
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subjects 631/250/127/1213
631/250/1619/554/1898/1273
631/250/249/1313
631/250/347
Allergology
Antibodies
Autoimmune diseases
Biomedical and Life Sciences
Biomedicine
Epithelial cells
Gastroenterology
Helper cells
Homeostasis
Immunology
Inflammation
Interleukin 10
Lymphocytes T
Phenotypes
Small intestine
title TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine
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