Regression of atherosclerosis with apple procyanidins by activating the ATP-binding cassette subfamily A member 1 in a rabbit model

Abstract Background and aims Apple polyphenol contains abundant procyanidins, which have been associated with an anti-atherosclerosis and cholesterol-lowering effect. The aim of this study was to investigate whether apple procyanidins (APCs) features therapeutic efficacy in terms of regressing ather...

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Veröffentlicht in:	Atherosclerosis 2017-03, Vol.258, p.56-64
Hauptverfasser:	Wang, Liang, Fumoto, Toshio, Masumoto, Saeko, Shoji, Toshihiko, Miura, Tomisato, Naraoka, Masato, Matsuda, Naoya, Imaizumi, Tadaatsu, Ohkuma, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-oxidant effect Aorta - drug effects Aorta - metabolism Aorta - pathology Aortic Diseases - metabolism Aortic Diseases - pathology Aortic Diseases - prevention & control Apple polyphenol Apple procyanidins Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Atherosclerotic plaque regression ATP Binding Cassette Transporter 1 - agonists ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism ATP-binding cassette Biflavonoids - isolation & purification Biflavonoids - pharmacology Cardiovascular Cardiovascular Agents - isolation & purification Cardiovascular Agents - pharmacology Catechin - isolation & purification Catechin - pharmacology Cholesterol - blood Disease Models, Animal Fruit - chemistry Lipoproteins, LDL - blood Male Malus - chemistry Oxidative Stress - drug effects Phytotherapy Plants, Medicinal Plaque, Atherosclerotic Proanthocyanidins - isolation & purification Proanthocyanidins - pharmacology Reactive Oxygen Species - blood RNA, Messenger - genetics RNA, Messenger - metabolism Scavenger Receptors, Class E - metabolism Subfamily A member 1 Time Factors Up-Regulation
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