Polyamines Protect Escherichia coli Cells from the Toxic Effect of Oxygen

Wild-type Escherichia coli cells grow normally in 95%$O_2/5\%\>CO_2$. In contrast, cells that cannot make polyamines because of mutations in the biosynthetic pathway are rapidly killed by incubation in 95%$O_2/5\%\>CO_2$. Addition of polyamines prevents the toxic effect of oxygen, permitting c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-03, Vol.100 (5), p.2261-2265
Hauptverfasser:	Chattopadhyay, Manas K., Tabor, Celia White, Tabor, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Amines - chemistry Amino acids Bacteria Biological Sciences Cadaverine - pharmacology Cell Division Cell growth Cell membranes Chromatography, High Pressure Liquid Cultured cells Cytoprotection Disease DNA - metabolism Escherichia coli - metabolism Escherichia coli - physiology Hydrogen Peroxide - pharmacology Mutation Oxidative Stress Oxygen Oxygen - metabolism Plasmids - metabolism Polyamines Polyamines - chemistry Polyamines - metabolism Polyamines - pharmacology Putrescine - pharmacology Slavic culture Sorbitol - chemistry Sorbitol - pharmacology Spermidine - pharmacology Sucrose - pharmacology Superoxide Dismutase - pharmacology Superoxides Time Factors
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