Modality of tumor endothelial VEGFR2 silencing-mediated improvement in intratumoral distribution of lipid nanoparticles

The vascular endothelial growth factor (VEGF)-mediated enhancement in vascular permeability is considered to be a major factor in tumor-targeting delivery via the enhanced permeability and retention (EPR) effect. We previously reported that the silencing of the endothelial VEGF receptor (VEGFR2) by...

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Veröffentlicht in:	Journal of controlled release 2017-04, Vol.251, p.1-10
Hauptverfasser:	Yamamoto, Shoshiro, Kato, Akari, Sakurai, Yu, Hada, Tomoya, Harashima, Hideyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Capillary Permeability Carcinoma, Renal Cell - blood supply Carcinoma, Renal Cell - metabolism Cell Line, Tumor Female Humans Intratumoral distribution Kidney Neoplasms - blood supply Kidney Neoplasms - metabolism Lipids - chemistry Liposome Liposomes Male Mice, Inbred BALB C Mice, Inbred ICR Mice, Nude Nanoparticles Oligopeptides - chemistry Particle Size Piperidines - chemistry Polyethylene Glycols - chemistry RNA, Small Interfering - genetics siRNA Tumor Microenvironment Tumor vasculature Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - genetics
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